MAGEA4

Melanoma-associated antigen 4 is a protein that in humans is encoded by the MAGEA4 gene.[3][4]

MAGEA4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1I4F, 2WA0
Identifiers
Aliases	MAGEA4, CT1.4, MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B, MAGE family member A4
External IDs	OMIM: 300175 HomoloGene: 134073 GeneCards: MAGEA4
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 151,912,509 bp[1] End 151,925,170 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • molecular function Cellular component • cellular component Biological process • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4103	n/a
Ensembl	ENSG00000147381	n/a
UniProt	P43358	n/a
RefSeq (mRNA)	NM_001011548 NM_001011549 NM_001011550 NM_002362	n/a
RefSeq (protein)	NP_001011548 NP_001011549 NP_001011550 NP_002353	n/a
Location (UCSC)	Chr X: 151.91 – 151.93 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000147381 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
4. "Entrez Gene: MAGEA4 melanoma antigen family A, 4".

Further reading

• Brasseur F, Rimoldi D, Liénard D, et al. (1995). "Expression of MAGE genes in primary and metastatic cutaneous melanoma". Int. J. Cancer. 63 (3): 375–80. doi:10.1002/ijc.2910630313. PMID 7591235.
• Imai Y, Shichijo S, Yamada A, et al. (1995). "Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens". Gene. 160 (2): 287–90. doi:10.1016/0378-1119(94)00680-Q. PMID 7642112.
• De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540.
• Ding M, Beck RJ, Keller CJ, Fenton RG (1994). "Cloning and analysis of MAGE-1-related genes". Biochem. Biophys. Res. Commun. 202 (1): 549–55. doi:10.1006/bbrc.1994.1963. PMID 8037761.
• De Plaen E, Naerhuyzen B, De Smet C, et al. (1997). "Alternative promoters of gene MAGE4a". Genomics. 40 (2): 305–13. doi:10.1006/geno.1996.4566. PMID 9119398.
• Hillig RC, Coulie PG, Stroobant V, et al. (2001). "High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene". J. Mol. Biol. 310 (5): 1167–76. doi:10.1006/jmbi.2001.4816. PMID 11502003.
• Yutani S, Tanaka M, Mutsumoto H, et al. (2005). "Elevation of serum MAGE-4 protein levels and prediction of hepatocellular carcinogenesis in patients with liver cirrhosis". Jpn. J. Cancer Res. 93 (4): 453–8. doi:10.1111/j.1349-7006.2002.tb01277.x. PMC 5927013. PMID 11985796.
• Kocher T, Zheng M, Bolli M, et al. (2002). "Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study". Int. J. Cancer. 100 (6): 702–5. doi:10.1002/ijc.10540. PMID 12209610.
• Resnick MB, Sabo E, Kondratev S, et al. (2002). "Cancer-testis antigen expression in uterine malignancies with an emphasis on carcinosarcomas and papillary serous carcinomas". Int. J. Cancer. 101 (2): 190–5. doi:10.1002/ijc.10585. PMID 12209997.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagao T, Higashitsuji H, Nonoguchi K, et al. (2003). "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity". J. Biol. Chem. 278 (12): 10668–74. doi:10.1074/jbc.M206104200. PMID 12525503.
• Sarcevic B, Spagnoli GC, Terracciano L, et al. (2003). "Expression of cancer/testis tumor associated antigens in cervical squamous cell carcinoma". Oncology. 64 (4): 443–9. doi:10.1159/000070305. PMID 12759544.
• Sakurai T, Itoh K, Higashitsuji H, et al. (2004). "A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells". J. Biol. Chem. 279 (15): 15505–14. doi:10.1074/jbc.M310437200. hdl:2433/147540. PMID 14739298.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Miyahara Y, Naota H, Wang L, et al. (2006). "Determination of cellularly processed HLA-A2402-restricted novel CTL epitopes derived from two cancer germ line genes, MAGE-A4 and SAGE". Clin. Cancer Res. 11 (15): 5581–9. doi:10.1158/1078-0432.CCR-04-2585. PMID 16061876.
• Hudolin T, Juretic A, Spagnoli GC, et al. (2006). "Immunohistochemical expression of tumor antigens MAGE-A1, MAGE-A3/4, and NY-ESO-1 in cancerous and benign prostatic tissue". Prostate. 66 (1): 13–8. doi:10.1002/pros.20312. PMID 16114059.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Yoshida N, Abe H, Ohkuri T, et al. (2006). "Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance". Int. J. Oncol. 28 (5): 1089–98. doi:10.3892/ijo.28.5.1089. PMID 16596224.
• Peikert T, Specks U, Farver C, et al. (2006). "Melanoma antigen A4 is expressed in non-small cell lung cancers and promotes apoptosis". Cancer Res. 66 (9): 4693–700. doi:10.1158/0008-5472.CAN-05-3327. PMID 16651421.