MAGEA12

Melanoma-associated antigen 12 is a protein that in humans is encoded by the MAGEA12 gene.[3][4]

MAGEA12
Identifiers
AliasesMAGEA12, CT1.12, MAGE12, MAGE family member A12
External IDsOMIM: 300177 HomoloGene: 88720 GeneCards: MAGEA12
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq28Start152,733,757 bp[1]
End152,737,669 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

4111

n/a

Ensembl

ENSG00000213401

n/a

UniProt

P43365

n/a

RefSeq (mRNA)

NM_005367
NM_001166386
NM_001166387

n/a

RefSeq (protein)

NP_001159858
NP_001159859
NP_005358

n/a

Location (UCSC)Chr X: 152.73 – 152.74 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.[4]

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References
  1. GRCh38: Ensembl release 89: ENSG00000213401 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Rogner UC, Wilke K, Steck E, Korn B, Poustka A (October 1995). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
  4. "Entrez Gene: MAGEA12 melanoma antigen family A, 12".

Further reading
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