Mannonate dehydratase

In enzymology, a mannonate dehydratase (EC 4.2.1.8) is an enzyme that catalyzes the chemical reaction

D-mannonate 2-dehydro-3-deoxy-D-gluconate + H2O
mannonate dehydratase
Identifiers
EC number4.2.1.8
CAS number9024-31-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, D-mannonate, and two products, 2-dehydro-3-deoxy-D-gluconate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include mannonic hydrolase, mannonate hydrolyase, altronic hydro-lyase, altronate hydrolase, D-mannonate hydrolyase, and D-mannonate hydro-lyase. This enzyme participates in pentose and glucuronate interconversions.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1TZ9.

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References
    • ASHWELL A, WAHBA AJ, HICKMAN J (1958). "A new pathway of uronic acid metabolism". Biochim. Biophys. Acta. 30 (1): 186–7. doi:10.1016/0006-3002(58)90257-9. PMID 13584413.
    • Robert-Baudouy JM, Stoeber FR (1973). "[Purification and properties of D-mannonate hydrolyase from Escherichia coli K12]". Biochim. Biophys. Acta. 309 (2): 473–85. doi:10.1016/0005-2744(73)90045-4. PMID 4581499.


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