Maleate hydratase

In enzymology, a maleate hydratase (EC 4.2.1.31) is an enzyme that catalyzes the chemical reaction

(R)-malate maleate + H2O
maleate hydratase
Identifiers
EC number4.2.1.31
CAS number37290-71-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, (R)-malate, and two products, maleate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (R)-malate hydro-lyase (maleate-forming). Other names in common use include D-malate hydro-lyase, malease, and (R)-malate hydro-lyase. This enzyme participates in butanoate metabolism.

References

    • Britten JS, Morell H, Taggart JV (1969). "Anion activation of maleate hydratase". Biochim. Biophys. Acta. 185 (1): 220–7. doi:10.1016/0005-2744(69)90296-4. PMID 5796106.
    • SACKS W, JENSEN CO (1951). "Malease, a hydrase from corn kernels". J. Biol. Chem. 192 (1): 231–6. PMID 14917669.


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