Maleate hydratase
In enzymology, a maleate hydratase (EC 4.2.1.31) is an enzyme that catalyzes the chemical reaction
- (R)-malate maleate + H2O
| maleate hydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.31 | ||||||||
| CAS number | 37290-71-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, (R)-malate, and two products, maleate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (R)-malate hydro-lyase (maleate-forming). Other names in common use include D-malate hydro-lyase, malease, and (R)-malate hydro-lyase. This enzyme participates in butanoate metabolism.
References
- Britten JS, Morell H, Taggart JV (1969). "Anion activation of maleate hydratase". Biochim. Biophys. Acta. 185 (1): 220–7. doi:10.1016/0005-2744(69)90296-4. PMID 5796106.
- SACKS W, JENSEN CO (1951). "Malease, a hydrase from corn kernels". J. Biol. Chem. 192 (1): 231–6. PMID 14917669.
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