Lupan-3beta,20-diol synthase

Lupan-3beta,20-diol synthase (EC 4.2.1.128, LUP1 (gene)) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (lupan-3beta,20-diol forming).[1][2] This enzyme catalyses the following chemical reaction

lupan-3beta,20-diol (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O
Lupan-3beta,20-diol synthase
Identifiers
EC number4.2.1.128
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The reaction occurs in the reverse direction.

References

  1. Segura MJ, Meyer MM, Matsuda SP (July 2000). "Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol". Organic Letters. 2 (15): 2257–9. doi:10.1021/ol006016b. PMID 10930257.
  2. Kushiro T, Hoshino M, Tsutsumi T, Kawai K, Shiro M, Shibuya M, Ebizuka Y (November 2006). "Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization". Organic Letters. 8 (24): 5589–92. doi:10.1021/ol062310d. PMID 17107079.
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