L-aspartate oxidase
In enzymology, a L-aspartate oxidase (EC 1.4.3.16) is an enzyme that catalyzes the chemical reaction
- L-aspartate + H2O + O2 oxaloacetate + NH3 + H2O2
L-aspartate oxidase | |||||||||
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Identifiers | |||||||||
EC number | 1.4.3.16 | ||||||||
CAS number | 69106-47-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The 3 substrates of this enzyme are L-aspartate, H2O, and O2, whereas its 3 products are oxaloacetate, NH3, and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is L-aspartate:oxygen oxidoreductase (deaminating). This enzyme participates in alanine and aspartate metabolism and nicotinate and nicotinamide metabolism. It employs one cofactor, FAD.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1J5P, 1KNP, and 1KNR.
gollark: Also, it appears so far as if personality stuff is an... emergent property, I think is the right term... of the lower-level neuron interactions, rather than emerging from quantum effects in one of the neurons or something.
gollark: Not at that stage of the process, no, just when gametes are being made.
gollark: If I'm remembering correctly, when a zygote is made you just get the 23 chromosomes in each gamete merging together into one thing of 46.
gollark: No it's not.
gollark: Are you seriously saying that *psychopaths* exist because of *quantum effects in the brain*?
References
- Nasu S, Wicks FD, Gholson RK (1982). "L-Aspartate oxidase, a newly discovered enzyme of Escherichia coli, is the B protein of quinolinate synthetase". J. Biol. Chem. 257 (2): 626–32. PMID 7033218.
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