Jonas Salk

Jonas Edward Salk (/sɔːlk/; born Jonas Salk; October 28, 1914 – June 23, 1995) was an American virologist and medical researcher who developed one of the first successful polio vaccines. He was born in New York City and attended the City College of New York and New York University School of Medicine, later choosing to do medical research instead of becoming a practicing physician. He began an internship at Mount Sinai Hospital in New York City in 1939.[1] Two years later, he was granted a fellowship at the University of Michigan, where he spent several years studying flu viruses with his mentor, Thomas Francis Jr.[2]

"Salk" redirects here. For other uses, see Salk (disambiguation).

Jonas Salk
Jonas Salk at Copenhagen Airport (May 1959)
Born
Jonas Salk

(1914-10-28)October 28, 1914
New York City, U.S.
DiedJune 23, 1995(1995-06-23) (aged 80)
La Jolla, California, U.S.
Resting placeEl Camino Memorial Park
San Diego, California
NationalityAmerican
Alma materCity College of New York
New York University
Known forFirst polio vaccine
Spouse(s)
Donna Lindsay
​
(
m. 1939; div. 1968)

​
(
m. 1970)
AwardsLasker Award (1956)
Scientific career
FieldsMedical research,
virology, and epidemiology
InstitutionsUniversity of Pittsburgh
Salk Institute
University of Michigan
Doctoral advisorThomas Francis Jr.
Signature

In 1947, Salk accepted a professorship in the School of Medicine at the University of Pittsburgh. It was there that he undertook a project to determine the number of different types of poliovirus, starting in 1948 with funding from the National Foundation for Infantile Paralysis. Salk saw an opportunity to extend this project towards developing a vaccine against polio, and he gathered a research team and devoted himself to this work for the next seven years.

The field trial set up to test the Salk vaccine was, according to O'Neill, "the most elaborate program of its kind in history, involving 20,000 physicians and public health officers, 64,000 school personnel, and 220,000 volunteers." Over 1.8 million schoolchildren took part in the trial.[3] Before the Salk vaccine was introduced in 1955, polio was considered one of the most serious public health problems in the world, and epidemics were increasingly devastating in the post-war United States. The 1952 U.S. epidemic, in which 3,145 people died and 21,269 were left with some form of paralysis, was the worst polio outbreak in the nation's history, and most of its victims were children.[4] According to a 2009 PBS documentary, "Apart from the atomic bomb, America's greatest fear was polio."[5]

News of the vaccine's success was first made public on April 12, 1955.[6] Salk was immediately hailed as a "miracle worker", and chose to not patent the vaccine or seek any profit from it in order to maximize its global distribution.[1] An immediate rush to vaccinate began in both the United States and around the world. Many countries began polio immunization campaigns using Salk's vaccine, including Canada, Sweden, Denmark, Norway, West Germany, the Netherlands, Switzerland, and Belgium. Less than 25 years later, domestic transmission of polio had been completely eliminated in the United States.

In 1963, Salk founded the Salk Institute for Biological Studies in La Jolla, California, which is today a center for medical and scientific research. He continued to conduct research and publish books in his later years, focusing in his last years on the search for a vaccine against HIV. Salk also campaigned vigorously for mandatory vaccination throughout the rest of his life, calling the universal vaccination of children against disease a "moral commitment".[7] Salk's personal papers are today stored in Geisel Library at the University of California, San Diego.[8][9]

Early life and education

Jonas Salk was born in New York City, New York, on October 28, 1914. His parents, Daniel and Dora (née Press) Salk, were Ashkenazi Jewish. Daniel was born in New Jersey to immigrant parents; and Dora, in Minsk, emigrated when she was twelve.[10][11] They had not received extensive formal education.[12] Jonas had two younger brothers, Herman and Lee, a renowned child psychologist.[13] The family moved from East Harlem to 853 Elsmere Place, the Bronx,[14] with some time spent in Queens at 439 Beach 69th Street, Arverne.[15]

When he was 13, Salk entered Townsend Harris High School, a public school for intellectually gifted students. Named after the founder of City College of New York (CCNY), it was, said Oshinsky, "a launching pad for the talented sons of immigrant parents who lacked the money—and pedigree—to attend a top private school." In high school "he was known as a perfectionist ... who read everything he could lay his hands on," according to one of his fellow students.[16] Students had to cram a four-year curriculum into just three years. As a result, most dropped out or flunked out, despite the school's motto "study, study, study." Of the students who graduated, however, most would have the grades to enroll in CCNY, noted for being a highly competitive college.[17]:96

Education

Salk enrolled in CCNY, from which he earned a Bachelor of Science degree in chemistry in 1934.[18] Oshinsky writes that "for working-class immigrant families, City College represented the apex of public higher education. Getting in was tough, but tuition was free. Competition was intense, but the rules were fairly applied. No one got an advantage based on an accident of birth."[17]

At his mother's urging, he put aside aspirations of becoming a lawyer and instead concentrated on classes necessary for admission to medical school. However, according to Oshinsky, the facilities at City College were "barely second rate." There were no research laboratories. The library was inadequate. The faculty contained few noted scholars. "What made the place special," he writes, "was the student body that had fought so hard to get there... driven by their parents.... From these ranks, of the 1930s and 1940s, emerged a wealth of intellectual talent, including more Nobel Prize winners—eight—and PhD recipients than any other public college except the University of California at Berkeley." Salk entered CCNY at the age of 15, a "common age for a freshman who had skipped multiple grades along the way."[17]:98

As a child, Salk did not show any interest in medicine or science in general. He said in an interview with the Academy of Achievement,[19] "As a child I was not interested in science. I was merely interested in things human, the human side of nature, if you like, and I continue to be interested in that."

Medical school

After City College, Salk enrolled in New York University to study medicine. According to Oshinsky, NYU based its modest reputation on famous alumni, such as Walter Reed, who helped conquer yellow fever. Tuition was "comparatively low, better still, it did not discriminate against Jews... while most of the surrounding medical schools—Cornell, Columbia, University of Pennsylvania, and Yale—had rigid quotas in place." Yale, for example, accepted 76 applicants in 1935 out of a pool of 501. Although 200 of the applicants were Jewish, only five got in.[17]:98 During his years at New York University Medical School, Salk worked as a laboratory technician during the school year and as a camp counselor in the summer.[18]

During Salk's medical studies, he stood out from his peers, according to Bookchin, "not just because of his continued academic prowess—he was Alpha Omega Alpha, the Phi Beta Kappa Society of medical education—but because he had decided he did not want to practice medicine." Instead, he became absorbed in research, even taking a year off to study biochemistry. He later focused more of his studies on bacteriology, which had replaced medicine as his primary interest. He said his desire was to help humankind in general rather than single patients.[16] "It was the laboratory work, in particular, that gave new direction to his life."[17]

Salk has said: "My intention was to go to medical school, and then become a medical scientist. I did not intend to practice medicine, although in medical school, and in my internship, I did all the things that were necessary to qualify me in that regard. I had opportunities along the way to drop the idea of medicine and go into science. At one point at the end of my first year of medical school, I received an opportunity to spend a year in research and teaching in biochemistry, which I did. And at the end of that year, I was told that I could, if I wished, switch and get a Ph.D. in biochemistry, but my preference was to stay with medicine. And, I believe that this is all linked to my original ambition, or desire, which was to be of some help to humankind, so to speak, in a larger sense than just on a one-to-one basis."[20]

Concerning his last year of medical school, Salk said: "I had an opportunity to spend time in elective periods in my last year in medical school, in a laboratory that was involved in studies on influenza. The influenza virus had just been discovered about a few years before that. And, I saw the opportunity at that time to test the question as to whether we could destroy the virus infectivity and still immunize. And so, by carefully designed experiments, we found it was possible to do so."[21]

Postgraduate research and early laboratory work

In 1941, during his postgraduate work in virology, Salk chose a two-month elective to work in the laboratory of Thomas Francis at the University of Michigan. Francis had recently joined the faculty of the medical school after working for the Rockefeller Foundation, where he had discovered the type B influenza virus. According to Bookchin, "the two-month stint in Francis's lab was Salk's first introduction to the world of virology—and he was hooked."[16]:25 After graduating from medical school, Salk began his residency at New York's prestigious[17] Mount Sinai Hospital, where he again worked in Francis's laboratory.[17] Salk then worked at the University of Michigan School of Public Health with Francis, on an army-commissioned project in Michigan to develop an influenza vaccine. He and Francis eventually perfected a vaccine that was soon widely used at army bases, where Salk discovered and isolated one of the strains of influenza that was included in the final vaccine.[16]:26

Polio research
Further information: Polio and Polio vaccine
President Franklin D. Roosevelt meeting with Basil O'Connor

In 1947, Salk became ambitious for his own lab and was granted one at the University of Pittsburgh School of Medicine, but the lab was smaller than he had hoped and he found the rules imposed by the university restrictive.[22] In 1948, Harry Weaver, the director of research at the National Foundation for Infantile Paralysis, contacted Salk. He asked Salk to find out if there were more types of polio than the three then known, offering additional space, equipment and researchers. For the first year he gathered supplies and researchers including Julius Youngner, Byron Bennett, L. James Lewis, and secretary Lorraine Friedman joined Salk's team, as well.[5][23] As time went on, Salk began securing grants from the Mellon family and was able to build a working virology laboratory.[16] He later joined the National Foundation for Infantile Paralysis's polio project established by President Franklin D. Roosevelt.[16][24]

Extensive publicity and fear of polio led to much increased funding, $67 million by 1955, but research continued on dangerous live vaccines.[6][17]:85–87 Salk decided to use the safer 'killed' virus, instead of weakened forms of strains of polio viruses like the ones used contemporaneously by Albert Sabin, who was developing an oral vaccine.[25]

After successful tests on laboratory animals, on July 2, 1952, assisted by the staff at the D.T. Watson Home for Crippled Children, Salk injected 43 children with his killed-virus vaccine. A few weeks later, Salk injected children at the Polk State School for the retarded and feeble-minded. In 1954 he tested the vaccine on about one million children, known as the polio pioneers. The vaccine was announced as safe on April 12, 1955.[6][24][26][27][28]

Salk in 1955 at the University of Pittsburgh
Magazine photo of Jonas Salk to O'Neill, "the most elaborate program of its kind in history, involving 20,000 physicians and public health officers, 64,000 school personnel, and 220,000 volunteers,"[6] with over 1.8 million school children participating in the trial.[3] A 1954 Gallup poll showed that more Americans knew about the polio field trials than could give the full name of the President.
March of Dimes poster circa 1957

The project became large, involving 100 million contributors to the March of Dimes, and 7 million volunteers.[6][29]:54 The foundation allowed itself to go into debt to finance the final research required to develop the Salk vaccine.[30] Salk worked incessantly for two-and-a-half years.[6][31]

Salk's inactivated polio vaccine was the first vaccine for the disease; it came into use in 1955.[32][33] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[34]

Becoming a public figure

Celebrity versus privacy
With David Ben-Gurion in Jerusalem, 1959

Salk preferred not to have his career as a scientist affected by too much personal attention, as he had always tried to remain independent and private in his research and life, but this proved to be impossible. "Young man, a great tragedy has befallen you—you've lost your anonymity", the television personality Ed Murrow said to Salk shortly after the onslaught of media attention.[35] When Murrow asked him, "Who owns this patent?", Salk replied, "Well, the people I would say. There is no patent. Could you patent the sun?"[36] The vaccine is calculated to be worth $7 billion had it been patented.[37] However, lawyers from the National Foundation for Infantile Paralysis did look into the possibility of a patent, but ultimately determined that the vaccine was not a patentable invention because of prior art.[38]

Salk served on the board of directors of the John D. and Catherine T. MacArthur Foundation.[39]

Author Jon Cohen noted, "Jonas Salk made scientists and journalists alike go goofy. As one of the only living scientists whose face was known the world over, Salk, in the public's eye, had a superstar aura. Airplane pilots would announce that he was on board and passengers would burst into applause. Hotels routinely would upgrade him into their penthouse suites. A meal at a restaurant inevitably meant an interruption from an admirer, and scientists approached him with drop-jawed wonder as though some of the stardust might rub off."[40]

For the most part, however, Salk was "appalled at the demands on the public figure he has become and resentful of what he considers to be the invasion of his privacy", wrote The New York Times, a few months after his vaccine announcement.[28] The Times article noted, "at 40, the once obscure scientist ... was lifted from his laboratory almost to the level of a folk hero." He received a presidential citation, a score of awards, four honorary degrees, half a dozen foreign decorations, and letters from thousands of fellow citizens. His alma mater, City College of New York, gave him an honorary degree as Doctor of Laws. But "despite such very nice tributes", The New York Times wrote, "Salk is profoundly disturbed by the torrent of fame that has descended upon him. ... He talks continually about getting out of the limelight and back to his laboratory ... because of his genuine distaste for publicity, which he believes is inappropriate for a scientist."[28]

During a 1980 interview, 25 years later, he said, "It's as if I've been a public property ever since, having to respond to external, as well as internal, impulses. ... It's brought me enormous gratification, opened many opportunities, but at the same time placed many burdens on me. It altered my career, my relationships with colleagues; I am a public figure, no longer one of them."[35]

Maintaining his individuality

"If Salk the scientist sounds austere", wrote The New York Times, "Salk the man is a person of great warmth and tremendous enthusiasm. People who meet him generally like him." A Washington newspaper correspondent commented, "He could sell me the Brooklyn Bridge, and I never bought anything before." Award-winning geneticist Walter Nelson-Rees called him "a renaissance scientist: brilliant, sophisticated, driven ... a fantastic creature."[41]:127

He enjoys talking to people he likes, and "he likes a lot of people", wrote the Times. "He talks quickly, articulately, and often in complete paragraphs." And "He has very little perceptible interest in the things that interest most people—such as making money." That belongs "in the category of mink coats and Cadillacs—unnecessary", he said.[28]

Establishing the Salk Institute
The Salk Institute at La Jolla

In the years after Salk's discovery, many supporters, in particular the National Foundation, "helped him build his dream of a research complex for the investigation of biological phenomena 'from cell to society'."[42] Called the Salk Institute for Biological Studies, it opened in 1963 in the San Diego neighborhood of La Jolla. Salk believed that the institution would help new and upcoming scientists along in their careers, as he said himself, "I thought how nice it would be if a place like this existed and I was invited to work there." This was something that Salk was deprived of early in his life, but due to his achievements, was able to provide for future scientists.

In 1966, Salk described his "ambitious plan for the creation of a kind of Socratic academy where the supposedly alienated two cultures of science and humanism will have a favorable atmosphere for cross-fertilization."[43] Author and journalist Howard Taubman explained:

Although he is distinctly future-oriented, Dr. Salk has not lost sight of the institute's immediate aim, which is the development and use of the new biology, called molecular and cellular biology, described as part physics, part chemistry and part biology. The broad-gauged purpose of this science is to understand man's life processes.

There is talk here of the possibility, once the secret of how the cell is triggered to manufacture antibodies is discovered, that a single vaccine may be developed to protect a child against many common infectious diseases. There is speculation about the power to isolate and perhaps eliminate genetic errors that lead to birth defects.

Dr. Salk, a creative man himself, hopes that the institute will do its share in probing the wisdom of nature and thus help enlarge the wisdom of man. For the ultimate purpose of science, humanism and the arts, in his judgment, is the freeing of each individual to cultivate his full creativity, in whichever direction it leads. ... As if to prepare for Socratic encounters such as these, the institute's architect, Louis Kahn, has installed blackboards in place of concrete facings on the walls along the walks.[43]

The New York Times, in a 1980 article celebrating the 25th anniversary of the Salk vaccine, described the current workings at the facility:

At the institute, a magnificent complex of laboratories and study units set on a bluff overlooking the Pacific, Dr. Salk holds the titles of founding director and resident fellow. His own laboratory group is concerned with the immunologic aspects of cancer and the mechanisms of autoimmune disease, such as multiple sclerosis, in which the immune system attacks the body's own tissues.[35]

In an interview about his future hopes at the institute, he said, "In the end, what may have more significance is my creation of the institute and what will come out of it, because of its example as a place for excellence, a creative environment for creative minds."

Francis Crick, codiscoverer of the structure of the DNA molecule, was a leading professor at the institute until his death in 2004.

The institute also served as the basis for Bruno Latour and Steve Woolgar's 1979 book Laboratory Life: The Construction of Scientific Facts.[44]

AIDS vaccine work

Beginning in the mid-1980s, Salk engaged in research to develop a vaccine for AIDS. He cofounded The Immune Response Corporation (IRC) with Kevin Kimberlin and patented Remune, an immunologic therapy, but was unable to secure liability insurance for the product.[45] The project was discontinued in 2007, twelve years after Salk's death.

Salk's "biophilosophy"
Jonas Salk during a 1988 Centers for Disease Control visit

In 1966, The New York Times referred to him as the "Father of Biophilosophy." According to Times journalist and author Howard Taubman, "he never forgets ... there is a vast amount of darkness for man to penetrate. As a biologist, he believes that his science is on the frontier of tremendous new discoveries; and as a philosopher, he is convinced that humanists and artists have joined the scientists to achieve an understanding of man in all his physical, mental and spiritual complexity. Such interchanges might lead, he would hope, to a new and important school of thinkers he would designate as biophilosophers."[43] Salk told his cousin, Joel Kassiday, at a meeting of the Congressional Clearinghouse on the Future on Capitol Hill in 1984 that he was optimistic that ways to prevent most human and animal diseases would eventually be developed. Salk said people must be prepared to take prudent risks, since "a risk-free society would become a dead-end society" without progress.

Salk describes his "biophilosophy" as the application of a "biological, evolutionary point of view to philosophical, cultural, social and psychological problems." He went into more detail in two of his books, Man's Unfolding, and The Survival of the Wisest. In an interview in 1980, he described his thoughts on the subject, including his feeling that a sharp rise and an expected leveling off in the human population would take place and eventually bring a change in human attitudes:

I think of biological knowledge as providing useful analogies for understanding human nature. ... People think of biology in terms of such practical matters as drugs, but its contribution to knowledge about living systems and ourselves will in the future be equally important. ... In the past epoch, man was concerned with death, high mortality; his attitudes were antideath, antidisease", he says. "In the future, his attitudes will be expressed in terms of prolife and prohealth. The past was dominated by death control; in the future, birth control will be more important. These changes we're observing are part of a natural order and to be expected from our capacity to adapt. It's much more important to cooperate and collaborate. We are the co-authors with nature of our destiny.[35]

His definition of a "biophilosopher" is "Someone who draws upon the scriptures of nature, recognizing that we are the product of the process of evolution, and understands that we have become the process itself, through the emergence and evolution of our consciousness, our awareness, our capacity to imagine and anticipate the future, and to choose from among alternatives."[46]

Just prior to his death, Salk was working on a new book along the theme of biophilosophy, privately reported to be titled Millennium of the Mind.

Personal life

The day after his graduation from medical school in 1939, Salk married Donna Lindsay, a master's candidate at the New York College of Social Work. David Oshinsky writes that Donna's father, Elmer Lindsay, "a wealthy Manhattan dentist, viewed Salk as a social inferior, several cuts below Donna's former suitors." Eventually, her father agreed to the marriage on two conditions: first, Salk must wait until he could be listed as an official M.D. on the wedding invitations, and second, he must improve his "rather pedestrian status" by giving himself a middle name."[17]:99

They had three children: Peter, Darrell, and Jonathan Salk. In 1968, they divorced and, in 1970, Salk married French painter Françoise Gilot.

Jonas Salk died from heart failure at the age of 80 on June 23, 1995, in La Jolla,[47] and was buried at El Camino Memorial Park in San Diego.[48]

Honors and recognition

... in recognition of his 'historical medical' discovery ... Dr. Salk's achievement is meritorious service of the highest magnitude and dimension for the commonwealth, the country and mankind." The governor, who had three children, said that "as a parent he was 'humbly thankful to Dr. Salk,' and as Governor, 'proud to pay him tribute'.[49]

  • 1955, City University of New York creates the Salk Scholarship fund which it awards to multiple outstanding pre-med students each year
  • 1956, awarded the Lasker Award
  • 1957, the Municipal Hospital building, where Salk conducted his polio research at the University of Pittsburgh, is renamed Jonas Salk Hall and is home to the university's School of Pharmacy and Dentistry.[50]
  • 1958, awarded the James D. Bruce Memorial Award
Salk's bronze bust in the Polio Hall of Fame

Because of Doctor Jonas E. Salk, our country is free from the cruel epidemics of poliomyelitis that once struck almost yearly. Because of his tireless work, untold hundreds of thousands who might have been crippled are sound in body today. These are Doctor Salk's true honors, and there is no way to add to them. This Medal of Freedom can only express our gratitude, and our deepest thanks.

Documentary films
  • In early 2009, the American Public Broadcasting Service aired its new documentary film, American Experience: The Polio Crusade.[5] The documentary, available on DVD, can also be viewed online at PBS's website.
  • On April 12, 2010, to help celebrate the 55th anniversary of the Salk vaccine, a new 66-minute documentary, The Shot Felt 'Round the World, had its world premiere. Directed by Tjardus Greidanus[57] and produced by Laura Davis,[58] the documentary was conceived by Hollywood screenwriter and producer Carl Kurlander to bring "a fresh perspective on the era."[59]
  • In 2014, actor and director Robert Redford, who was once struck with a mild case of polio when he was a child, directed a documentary about the Salk Institute in La Jolla.[60]

Salk's book publications
  • Man Unfolding (1972)
  • Survival of the Wisest (1973)
  • World Population and Human Values: A New Reality (1981)
  • Anatomy of Reality: Merging of Intuition and Reason (1983)
gollark: It doesn't replicate itself *on here*.
gollark: DISCLAIMER: PotatOS is considered "malware" by a number of organizations. This is required by rule something.
gollark: You should run PotatOS on your street signs.
gollark: https://en.m.wikipedia.org/wiki/No-communication_theorem
gollark: https://xkcd.com/1591

See also

References
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  3. Rose DR (2004). "Fact Sheet—Polio Vaccine Field Trial of 1954." March of Dimes Archives. 2004 02 11.
  4. Zamula E (1991). "A New Challenge for Former Polio Patients." FDA Consumer 25 (5): 21–5. FDA.gov, Cited in Poliomyelitis [Retrieved November 14, 2009].
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  6. O'Neill, William L. (1989). American High: The Years of Confidence, 1945–1960. New York: Simon and Schuster. ISBN 0-02-923679-7.
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  9. San Diego Union Tribune, 20 March 2014: "UCSD to house Salk's papers", accessed July 3, 2015.
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  14. Roberts, Sam (July 27, 2012). "New York Census Data, Centuries Old, Is Now Online".
  15. City College of New York Microcosm Yearbook, 1934
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  21. "Archived copy". Archived from the original on July 22, 2015. Retrieved August 14, 2015.CS1 maint: archived copy as title (link)
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  30. Fleischer, Doris Z. The Disability Rights Movement: From Charity to Confrontation Temple University Press (2001)
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  34. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  35. Glueck, Grace. "Salk Studies Man's Future" The New York Times, April 8, 1980
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  40. Cohen, Jon (2001). Shots in the Dark: The Wayward Search for an AIDS Vaccine. New York: W.W. Norton & Co. ISBN 0-393-05027-0.
  41. Gold, Michael. A Conspiracy of Cells, State Univ. of NY Press, (1985)
  42. "Salk 25 years after vaccine", Detroit Free Press, April 9, 1980, p. 31.
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  45. Remune (HIV-1 Immunogen, Salk vaccine) Archived March 21, 2009, at the Wayback Machine AIDSmeds.com
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  56. The Guardian: Jonas Salk Google doodle, accessdate: September 14, 2015
  57. "IMDB bio of director Tjardus Greidanus". Internet Movie Database. Retrieved October 28, 2014.
  58. "IMDB bio of Laura Davis". Internet Movie Database. Retrieved October 28, 2014.
  59. "Film reveals Pittsburgh's polio stories" Pittsburgh Post-Gazette, April 14, 2010
  60. Bell, Diane (June 30, 2014). "Director Robert Redford gives sneak preview in La Jolla of his Salk Institute documentary film". The San Diego Union-Tribune. Retrieved April 29, 2020.

Further reading
  • Jacobs, Charlotte DeCroes. Jonas Salk: A Life, Oxford Univ. Press (2015), scholarly biography
  • Kluger, Jeffrey. Splendid Solution: Jonas Salk and the Conquest of Polio, Berkley Books (2006), history of the polio vaccine
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