Irreversible agonist

An irreversible agonist is a type of agonist that binds permanently to a receptor in such a manner that the receptor is permanently activated. It is distinct from a mere (reversible) agonist in that the association of an agonist to a receptor is reversible, whereas the binding of an irreversible agonist to a receptor is, at least in theory, irreversible. Oxymorphazone is an example of an irreversible agonist.[1] In practice, the distinction may be more a matter of degree, in which the binding affinity of an irreversible agonist is some orders of magnitude greater than that of an agonist.

Examples
gollark: Isn't water vapour a greenhouse gas too, though?
gollark: You could also point the orbital mirrors at population centres.
gollark: Oops.
gollark: In any case, I don't think anyone reasonable is projecting that climate change will kill most of the human population in 70 years.
gollark: If I understand the stuff on https://en.m.wikipedia.org/wiki/IPCC_list_of_greenhouse_gases right, then NO2 is responsible for only ~10% of greenhouse gas effects, and quite consistently that.

See also

References
  1. Galetta S, Ling GS, Wolfin L, Pasternak GW (Sep 1982), "Receptor binding and analgesic properties of oxymorphazone", Life Sciences, 31 (12–13): 1389–92, doi:10.1016/0024-3205(82)90388-5, PMID 6183551CS1 maint: uses authors parameter (link)
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