Glycosuria

Glycosuria is the excretion of glucose into the urine. Ordinarily, urine contains no glucose because the kidneys are able to reabsorb all of the filtered glucose from the tubular fluid back into the bloodstream. Glycosuria is nearly always caused by elevated blood glucose levels, most commonly due to untreated diabetes mellitus. Rarely, glycosuria is due to an intrinsic problem with glucose reabsorption within the kidneys (such as Fanconi syndrome), producing a condition termed renal glycosuria.[1] Glycosuria leads to excessive water loss into the urine with resultant dehydration, a process called osmotic diuresis.

Glycosuria
Other namesGlucosuria
SpecialtyEndocrinology

Alimentary glycosuria is a temporary condition, when a high amount of carbohydrate is taken, it is rapidly absorbed in some cases where a part of the stomach is surgically removed, the excessive glucose appears in urine producing glycosuria.

Pathophysiology

Blood is filtered by millions of nephrons, the functional units that comprise the kidneys. In each nephron, blood flows from the arteriole into the glomerulus, a tuft of leaky capillaries. The Bowman's capsule surrounds each glomerulus, and collects the filtrate that the glomerulus forms. The filtrate contains waste products (e.g. urea), electrolytes (e.g. sodium, potassium, chloride), amino acids, and glucose. The filtrate passes into the renal tubules of the kidney. In the first part of the renal tubule, the proximal tubule, glucose is reabsorbed from the filtrate, across the tubular epithelium and into the bloodstream. The proximal tubule can only reabsorb a limited amount of glucose (~375 mg/min[2]), known as the transport maximum. When the blood glucose level exceeds about 160–180 mg/dL (8.9-10 mmol/L), the proximal tubule becomes overwhelmed and begins to excrete glucose in the urine.

Approximate correlation between dipstick designation and plasma concentration of glucose
Urine dipstick
designation		Approximate plasma
concentration
trace100 mg/dL [3]
1+250 mg/dL[3] df
2+500 mg/dL[3]
3+1000 mg/dL[3]
4+2000 mg/dL[3]

This point is called the renal threshold for glucose (RTG).[4] Some people, especially children and pregnant women, may have a low RTG (less than ~7 mmol/L[4] glucose in blood to have glucosuria).

If the RTG is so low that even normal blood glucose levels produce the condition, it is referred to as renal glycosuria.

Glucose in urine can be identified by Benedict's qualitative test.

If yeast is present in the bladder, the sugar in the urine may begin to ferment, producing a rare condition known as urinary auto-brewery syndrome.

Medical induction with glycosuric drugs

Glycosuria can be induced therapeutically for treatment of diabetes mellitus type 2 using SGLT2 inhibitors canagliflozin, dapagliflozin, and empagliflozin (collectively known as gliflozins).

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References
  1. Rose, Burton; Rennke, Helmut (1994). Renal pathophysiology – the essentials (1st ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 194. ISBN 0-683-07354-0.
  2. DeFronzo, Ralph A.; Hompesch, Marcus; Kasichayanula, Sreeneeranj; Liu, Xiaoni; Hong, Ying; Pfister, Marc; Morrow, Linda A.; Leslie, Bruce R.; Boulton, David W. (October 2013). "Characterization of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and Subjects With Type 2 Diabetes". Diabetes Care. 36 (10): 3169–3176. doi:10.2337/dc13-0387. ISSN 0149-5992. PMC 3781504. PMID 23735727.
  3. Han BR, Oh YS, Ahn KH, Kim HY, Hong SC, Oh MJ, Kim HJ, Kim YT, Lee KW, Kim SH. BR, Han (Sep 2010). "Clinical Implication of 2nd Trimester Glycosuria". Korean J Perinatol. 21 (3): 258–65.
  4. AIDA on-line' Explanations
Classification
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