Glycolaldehyde dehydrogenase
In enzymology, a glycolaldehyde dehydrogenase (EC 1.2.1.21) is an enzyme that catalyzes the chemical reaction
- glycolaldehyde + NAD+ + H2O glycolate + NADH + 2 H+
| glycolaldehyde dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.2.1.21 | ||||||||
| CAS number | 37250-89-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are glycolaldehyde, NAD+, and H2O, whereas its 3 products are glycolate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolaldehyde:NAD+ oxidoreductase. This enzyme is also called glycol aldehyde dehydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HG2, 2ILU, and 2IMP.
gollark: I'll have to make it ignore *itself* too!
gollark: I just removed all the checks for testing.
gollark: It responds to itself.
gollark: Oops.
gollark: ```pythonimport syswith open(sys.argv[0]) as f: code = f.read()b = "`" * 3print(f"++exec {b}python\n{code}\n{b}")```
References
- Davies DD (1960). "The purification and properties of glycolaldehyde dehydrogenase". J. Exp. Bot. 11: 289–295. doi:10.1093/jxb/11.3.289.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.