Gluconate dehydratase
In enzymology, a gluconate dehydratase (EC 4.2.1.39) is an enzyme that catalyzes the chemical reaction
- D-gluconate 2-dehydro-3-deoxy-D-gluconate + H2O
| gluconate dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.39 | ||||||||
| CAS number | 37290-75-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, D-gluconate, and two products, 2-dehydro-3-deoxy-D-gluconate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include D-gluconate dehydratase, and D-gluconate hydro-lyase. This enzyme participates in pentose phosphate pathway.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1QJ4.
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References
- Andreesen JR, Gottschalk G (1969). "The occurrence of a modified Entner-doudoroff pathway in Clostridium aceticum". Arch. Mikrobiol. 69 (2): 160–70. doi:10.1007/BF00409760. PMID 5383859.
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