Gluconate dehydratase
In enzymology, a gluconate dehydratase (EC 4.2.1.39) is an enzyme that catalyzes the chemical reaction
- D-gluconate 2-dehydro-3-deoxy-D-gluconate + H2O
| gluconate dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.39 | ||||||||
| CAS number | 37290-75-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, D-gluconate, and two products, 2-dehydro-3-deoxy-D-gluconate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include D-gluconate dehydratase, and D-gluconate hydro-lyase. This enzyme participates in pentose phosphate pathway.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1QJ4.
gollark: <@&198138780132179968> <@270035320894914560>/aus210 has stolen my (enchanted with Unbreaking something/Mending) elytra.I was in T79/i02p/n64c/pjals' base (aus210 wanted help with some code, and they live in the same place with some weird connecting tunnels) and came across an armor stand (it was in an area of the base I was trusted in - pjals sometimes wants to demo stuff to me or get me to help debug, and the claim organization is really odd). I accidentally gave it my neural connector, and while trying to figure out how to get it back swapped my armor onto it (turns out shiftrightclick does that). Eventually I got them both back, but while my elytra was on the stand aus210 stole it. I asked for it back and they repeatedly denied it.They have claimed:- they can keep it because I intentionally left it there (this is wrong, and I said so)- there was no evidence that it was mine so they can keep it (...)EDIT: valithor got involved and got them to actually give it back, which they did after ~10 minutes of generally delaying, apparently leaving it in storage, and dropping it wrong.
gollark: Someone had a problem with two mutually recursive functions (one was defined after the other), so I fixed that for them. Then I explained stack overflows and how that made their design (`mainScreen` calls `itemScreen` calls `mainScreen`...) problematic. Their suggested solution was to just capture the error and restart the program. Since they weren't entirely sure how to do *that*, their idea was to make it constantly ping their webserver and have another computer reboot it if it stopped.
gollark: potatOS is also secure <@!290217153293189120> ke
gollark: Probably.
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References
- Andreesen JR, Gottschalk G (1969). "The occurrence of a modified Entner-doudoroff pathway in Clostridium aceticum". Arch. Mikrobiol. 69 (2): 160–70. doi:10.1007/BF00409760. PMID 5383859.
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