Gluconate dehydratase

In enzymology, a gluconate dehydratase (EC 4.2.1.39) is an enzyme that catalyzes the chemical reaction

D-gluconate 2-dehydro-3-deoxy-D-gluconate + H2O
gluconate dehydratase
Identifiers
EC number4.2.1.39
CAS number37290-75-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, D-gluconate, and two products, 2-dehydro-3-deoxy-D-gluconate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include D-gluconate dehydratase, and D-gluconate hydro-lyase. This enzyme participates in pentose phosphate pathway.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1QJ4.

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References

    • Andreesen JR, Gottschalk G (1969). "The occurrence of a modified Entner-doudoroff pathway in Clostridium aceticum". Arch. Mikrobiol. 69 (2): 160–70. doi:10.1007/BF00409760. PMID 5383859.


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