Glucarate dehydratase

In enzymology, a glucarate dehydratase (EC 4.2.1.40) is an enzyme that catalyzes the chemical reaction

D-glucarate 5-dehydro-4-deoxy-D-glucarate + H2O
glucarate dehydratase
glucarate dehydratase tetramer, E.Coli
Identifiers
EC number4.2.1.40
CAS number9059-02-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, D-glucarate, and two products, 5-dehydro-4-deoxy-D-glucarate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming). Other names in common use include D-glucarate dehydratase, and D-glucarate hydro-lyase. This enzyme participates in ascorbate and aldarate metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1BQG, 1EC7, 1EC8, 1EC9, 1ECQ, 1JCT, and 1JDF.

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References

    • Blumenthal HJ (1966). "D-Glucarate dehydrase". Methods Enzymol. 9: 660–665. doi:10.1016/0076-6879(66)09134-1.


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