Fusicocca-2,10(14)-diene synthase

Fusicocca-2,10(14)-diene synthase (EC 4.2.3.43, fusicoccadiene synthase, PaFS, PaDC4) is an enzyme with systematic name geranylgeranyl diphosphate-lyase (fusicocca-2,10(14)-diene-forming).[1] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate fusicocca-2,10(14)-diene + diphosphate
Fusicocca-2,10(14)-diene synthase
Identifiers
EC number4.2.3.43
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This multifunctional enzyme also has EC 2.5.1.29, farnesyltranstransferase, activity.

References

  1. Toyomasu T, Tsukahara M, Kaneko A, Niida R, Mitsuhashi W, Dairi T, Kato N, Sassa T (February 2007). "Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi". Proceedings of the National Academy of Sciences of the United States of America. 104 (9): 3084–8. doi:10.1073/pnas.0608426104. PMC 1805559. PMID 17360612.
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