Flocoumafen

Flocoumafen is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It is a second generation (i.e., high potency) chemical in this class, used commercially as a rodenticide. It has a very high toxicity and is restricted to indoor use and sewers (in the UK). This restriction is mainly due to the increased risk to non-target species, especially due to its tendency to bio-accumulate in exposed organisms. Studies have shown that rodents resistant to first-generation anticoagulants can be adequately controlled with flocoumafen. It was synthesized in 1984 by Shell International Chemical.[1]

Flocoumafen
Names
IUPAC name
2-Hydroxy-3-[3-[4-([4-(trifluoromethyl)phenyl]methoxy)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl] chromen-4-one
Identifiers
3D model (JSmol)
ECHA InfoCard 100.102.053
KEGG
UNII
Properties
C33H25F3O4
Molar mass 542.54441
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Toxicity

To most rodents LD50 is 1 mg/kg, but it can vary a lot between species: from 0.12 mg/kg: Microtus arvalis to more than 10 mg/kg Acomys cahirinus. For dogs: 0.075 - 0.25 mg/kg.[1]

Antidote

Antidote is vitamin K1.

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References
  1. Flocoumafen -- A new anticoagulant rodenticide

See also
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