Ferric-chelate reductase
In enzymology, a ferric-chelate reductase (EC 1.16.1.7) is an enzyme that catalyzes the chemical reaction
- 2 Fe(II) + NAD+ 2 Fe(III) + NADH + H+
| ferric-chelate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.16.1.7 | ||||||||
| CAS number | 122097-10-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are Fe(II) and NAD+, whereas its 3 products are Fe(III), NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is Fe(II):NAD+ oxidoreductase. Other names in common use include ferric chelate reductase, iron chelate reductase, NADH:Fe3+-EDTA reductase, and NADH2:Fe3+ oxidoreductase.
References
- Askerlund P, Larsson C, Widell S (1988). "Localization of donor and acceptor sites of NADH dehydrogenase activities using inside-out and right-side-out plasma membrane vesicles from plants". FEBS Lett. 239: 23–28. doi:10.1016/0014-5793(88)80538-6.
- Freitas MP (2006). "MIA-QSAR modelling of anti-HIV-1 activities of some 2-amino-6-arylsulfonylbenzonitriles and their thio and sulfinyl congeners". Org. Biomol. Chem. 4 (6): 1154–9. doi:10.1039/b516396j. PMID 16525561.
- Freitas MP (2006). "MIA-QSAR modelling of anti-HIV-1 activities of some 2-amino-6-arylsulfonylbenzonitriles and their thio and sulfinyl congeners". Org. Biomol. Chem. 4 (6): 1154–9. doi:10.1039/b516396j. PMID 16525561.
- Buckhout TJ, Hrubec TC (1986). "Pyridine nucleotide-dependent ferricyanide reduction associated with isolated plasma membranes of maize (Zea mays L.) roots". Protoplasma. 135 (2–3): 144–154. doi:10.1007/BF01277007.
- Sandelius AS, Barr R, Crane FL, Morre DJ (1986). "Redox reactions of plasma membranes isolated from soybean hypocotyls by phase partition". Plant Sci. 48: 1–10. doi:10.1016/0168-9452(87)90062-8.
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