Leukotriene D4

Leukotriene D4
Identifiers
CAS Number	73836-78-9 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:28666 ;
ChEMBL	ChEMBL288943 ;
ChemSpider	4444401 ;
MeSH	Leukotriene+D4
PubChem CID	5280878;
UNII	5FNY4416UE ;
CompTox Dashboard (EPA)	DTXSID6040533 ;
	InChI InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 Key: YEESKJGWJFYOOK-IJHYULJSSA-N ; InChI=1/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 Key: YEESKJGWJFYOOK-IJHYULJSBX;
	SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O;
Properties
Chemical formula	C25H40N2O6S
Molar mass	496.661 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Leukotriene D₄ (LTD₄) is one of the leukotrienes. Its main function in the body is to induce the contraction of smooth muscle, resulting in bronchoconstriction and vasoconstriction. It also increases vascular permeability. LTD₄ is released by basophils. Other leukotrienes that function in a similar manner are leukotrienes C₄ and E₄. Pharmacological agents that inhibit the function of these leukotrienes are leukotriene receptor antagonists (e.g. Zafirlukast, montelukast) and are useful for asthmatic individuals.

Eicosanoid synthesis. (Leukotrienes at right.)

References

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