Leukotriene B4

Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. It has been shown to promote insulin resistance in obese mice.

Leukotriene B4
Names
IUPAC name
(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenoic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
KEGG
UNII
Properties
C20H32O4
Molar mass 336.466
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Biochemistry

Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue.[1] In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosomal enzymes by these cells.[1] It is synthesized by leukotriene-A4 hydrolase from leukotriene A4.[2]

Eicosanoid synthesis. (Leukotrienes at right.)

Diabetes

A study at the University of California, San Diego School of Medicine has shown that leukotriene B4 promotes insulin resistance in obese mice.[3] Obesity is the major cause of type 2 diabetes insulin resistance.[4]

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References
  1. Cotran; Kumar, Collins (1999). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.
  2. https://www.uniprot.org/uniprot/P09960. Retrieved 9 April 2013. Missing or empty |title= (help)
  3. UCSanDiego Press Release
  4. Li, P; Oh, DY; Bandyopadhyay, G; Lagakos, WS; Talukdar, S; Osborn, O; Johnson, A; Chung, H; Maris, M; Ofrecio, JM; Taguchi, S; Lu, M; Olefsky, JM (2015). "LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes". Nature Medicine. 21 (3): 239–247. doi:10.1038/nm.3800. PMC 4429798. PMID 25706874.


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