FTH1

Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene.[5][6]

FTH1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFTH1, FHC, FTH, FTHL6, HFE5, PIG15, PLIF, ferritin, heavy polypeptide 1, ferritin heavy chain 1
External IDsOMIM: 134770 MGI: 95588 HomoloGene: 74295 GeneCards: FTH1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q12.3Start61,959,718 bp[1]
End61,967,634 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2495

14319

Ensembl

ENSG00000167996

ENSMUSG00000024661

UniProt

P02794

P09528

RefSeq (mRNA)

NM_002032

NM_010239

RefSeq (protein)

NP_002023

NP_034369

Location (UCSC)Chr 11: 61.96 – 61.97 MbChr 19: 9.98 – 9.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.[6]

Interactions

FTH1 has been shown to interact with Ferritin light chain.[7][8]

gollark: Future MC.
gollark: I may be off for a bit, since a mod recently updated and now mcdex is confused.
gollark: So where's the new facility?
gollark: Seems to be working fine and not crashing...
gollark: This does mean I can't just revert to backup, which is irritating.

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000167996 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024661 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hentze MW, Keim S, Papadopoulos P, O'Brien S, Modi W, Drysdale J, Leonard WJ, Harford JB, Klausner RD (Oct 1986). "Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene". Proceedings of the National Academy of Sciences of the United States of America. 83 (19): 7226–30. doi:10.1073/pnas.83.19.7226. PMC 386688. PMID 3020541.
  6. "Entrez Gene: FTH1 ferritin, heavy polypeptide 1".
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  8. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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