FKBPL

FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPL gene.[4]

FKBPL
Identifiers
Aliases	FKBPL, DIR1, NG7, WISP39, FKBP4, FK506 binding protein like, FKBP prolyl isomerase like
External IDs	OMIM: 617076 MGI: 1932127 HomoloGene: 10529 GeneCards: FKBPL
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,128,707 bp[1] End 32,130,288 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytosol • extracellular region Biological process • response to radiation • protein stabilization • regulation of angiogenesis • regulation of blood vessel branching Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	63943	56299
Ensembl	ENSG00000204315 ENSG00000230907 ENSG00000224200 ENSG00000223666	n/a
UniProt	Q9UIM3	O35450
RefSeq (mRNA)	NM_022110	NM_019873
RefSeq (protein)	NP_071393 NP_071393.2	NP_063926
Location (UCSC)	Chr 6: 32.13 – 32.13 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.[5]

FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.[6] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.[7]

It is known to interact with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling, like other FKBPs.[8]

FKBPL has also been shown to influence estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug tamoxifen.[9]

References

1. ENSG00000230907, ENSG00000224200, ENSG00000223666 GRCh38: Ensembl release 89: ENSG00000204315, ENSG00000230907, ENSG00000224200, ENSG00000223666 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Robson TA, Lohrer H, Bailie JR, Hirst DG, Joiner MC, Arrand JE (February 1997). "Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line". Biochem. Soc. Trans. 25 (1): 335–42. doi:10.1042/bst0250335. PMID 9056895.
5. "Entrez Gene: FKBPL".
6. Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I, Jones H, McKeown SR, Hirst DG (November 1999). "A novel human stress response-related gene with a potential role in induced radioresistance". Radiat. Res. 152 (5): 451–61. doi:10.2307/3580140. JSTOR 3580140. PMID 10521921.
7. Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A (January 2005). "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein". Mol. Cell. 17 (2): 237–49. doi:10.1016/j.molcel.2004.11.049. PMID 15664193.
8. McKeen HD, McAlpine K, Valentine A, Quinn DJ, McClelland K, Byrne C, O'Rourke M, Young S, Scott CJ, McCarthy HO, Hirst DG, Robson T (July 2008). "A novel FK506-like binding protein (FKBPL) interacts with the glucocorticoid receptor and regulates steroid receptor signalling". Endocrinology. 149 (11): 5724–34. doi:10.1210/en.2008-0168. PMID 18669603.
9. McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T (February 2010). "FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy". Cancer Res. 70 (3): 1090–100. doi:10.1158/0008-5472.CAN-09-2515. PMID 20103631.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.