Ethylmalonyl-CoA decarboxylase
Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) is an enzyme with systematic name (S)-ethylmalonyl-CoA carboxy-lyase (butanoyl-CoA-forming).[5] This enzyme catalyses the following chemical reaction
- (S)-ethylmalonyl-CoA butanoyl-CoA + CO2
ECHDC1 | |||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||
Aliases | ECHDC1, HEL-S-76, MMCD, dJ351K20.2, ethylmalonyl-CoA decarboxylase 1 | ||||||||||||||||||||||||
External IDs | OMIM: 612136 MGI: 1277169 HomoloGene: 23106 GeneCards: ECHDC1 | ||||||||||||||||||||||||
EC number | 7.2.4.3 | ||||||||||||||||||||||||
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Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
UniProt | |||||||||||||||||||||||||
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RefSeq (protein) | |||||||||||||||||||||||||
Location (UCSC) | Chr 6: 127.29 – 127.34 Mb | Chr 10: 29.31 – 29.35 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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Ethylmalonyl-CoA decarboxylase | |||||||||
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Identifiers | |||||||||
EC number | 4.1.1.94 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The vertebrate enzyme decarboxylates ethylmalonyl-CoA.
References
- GRCh38: Ensembl release 89: ENSG00000093144 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000019883 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Linster CL, Noël G, Stroobant V, Vertommen D, Vincent MF, Bommer GT, Veiga-da-Cunha M, Van Schaftingen E (Dec 2011). "Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading". The Journal of Biological Chemistry. 286 (50): 42992–3003. doi:10.1074/jbc.m111.281527. PMC 3234807. PMID 22016388.
External links
- Ethylmalonyl-CoA+decarboxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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