Ethanolamine ammonia-lyase

In enzymology, an ethanolamine ammonia-lyase (EC 4.3.1.7) is an enzyme that catalyzes the chemical reaction

ethanolamine acetaldehyde + NH3
ethanolamine ammonia-lyase
Identifiers
EC number4.3.1.7
CAS number9054-69-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, ethanolamine, and two products, acetaldehyde and NH3.

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is ethanolamine ammonia-lyase (acetaldehyde-forming). This enzyme is also called ethanolamine deaminase. This enzyme participates in glycerophospholipid metabolism. It employs one cofactor, adenosylcobalamin.

Structural studies

As of early 2011, several structures have been solved for this class of enzymes. The first structure solved was the active site containing EutB subunit of EAL from Listeria monocytogenes with the PDB accession code 2QEZ. Later, more structures have become available from Escherichia coli that include both EAL subunits bound to various ligands.

gollark: Nobody's done it on SC yet, though automated commodity markets would be extremely cool.
gollark: Is hard.
gollark: There's some stuff which is somewhat annoying and complex to produce, so there could be a brisk trade in that.
gollark: Again, not everyone actually does automate all the stuff they might want.
gollark: GT:NH does that.

References
    • Bradbeer C (1965). "The clostridial fermentations of choline and ethanolamine. 1 Preparation and properties of cell-free extracts". J. Biol. Chem. 240 (12): 4669–74. PMID 5846987.
    • Bradbeer C (1965). "The clostridial fermentations of choline and ethanolamine. II Requirement for a cobamide coenzyme by an ethanolamine deaminase". J. Biol. Chem. 240 (12): 4675–81. PMID 5846988.
    • Kaplan BH, Stadtman ER (1968). "Ethanolamine deaminase, a cobamide coenzyme-dependent enzyme. I Purification, assay, and properties of the enzyme". J. Biol. Chem. 243 (8): 1787–93. PMID 4297225.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.