Epi-isozizaene synthase

Epi-isozizaene synthase (EC 4.2.3.37, SCO5222 protein) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-epi-isozizaene-forming).[1][2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate (+)-epi-isozizaene + diphosphate
Epi-isozizaene synthase
Identifiers
EC number4.2.3.37
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme requires Mg2+ for activity.

References

  1. Lin X, Hopson R, Cane DE (May 2006). "Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase". Journal of the American Chemical Society. 128 (18): 6022–3. doi:10.1021/ja061292s. PMC 2533732. PMID 16669656.
  2. Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE (March 2008). "Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)". The Journal of Biological Chemistry. 283 (13): 8183–9. doi:10.1074/jbc.M710421200. PMC 2276382. PMID 18234666.


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