Eosinophilic ulcer of the oral mucosa

Eosinophilic ulcer of the oral mucosa
Other names	Eosinophilic ulcer of the tongue,[1] Riga–Fede disease,[1]
	Eosinophilic ulcer of the oral mucosa – H&E stain

Eosinophilic ulcer of the oral mucosa (also known as traumatic eosinophilic granuloma[1]) is a condition characterized by an ulcer with an indurated and elevated border.[2]^:803 The lesion might be tender, fast-growing and the patient often not be aware of any trauma in the area.

Causes

It is often associated with trauma. However, other causes are suspected, such as drugs, inherent predisposition, immune reaction, or lymphoproliferative disorder.

Diagnosis

Differential Diagnosis

Squamous Cell Carcinoma, Pyogenic granulomas, Lesions of a chronic granulomatous disease and Mesenchymal tumors

Definition

Traumatic eosinophilic granuloma of the tongue (TEGT) is a reactive condition that commonly occurs on the ventral tongue.

Treatment

When the lesion is excised, recurrence often occurs. Palliative care with nonsteroidal anti-inflammatory drugs (NSAIDs) may be used, and topical steroids can be curative. If the lesion does not respond to treatment, biopsy is required.

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References

Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.

3. Ficarra G, Prignano F, Romagnoli P. Traumatic eosinophilic granuloma of the oral mucosa: A lymphoproliferative disorder? Oral Oncol.1997;33(5):375-379.

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[Bolognia-1] Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.

[Andrews-2] James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.