Giant-cell fibroma

Giant-cell fibroma is a type of fibroma not associated with trauma or irritation. It can occur at any age and on a mucous membrane surface. The most common oral locations are on the gingiva of the mandible, tongue, and palate. It is a localized reactive proliferation of fibrous connective tissue.

Giant-cell fibroma (GCF) is a benign non-neoplastic lesion first described by Weathers and Callihan (1974). It occurs in the first three decades of life and predominates in females (Houston, 1982; Bakos, 1992). Clinically, the GCF presents as an asymptomatic, papillary and pedunculated lesion. The most predominant location is the mandibular gingiva (Houston, 1982; Bakos, 1992). Histologically, the GCF is distinctive, consisting of fibrous connective tissue without inflammation and covered with stratified squamous hyperplastic epithelium. The most characteristic histological feature is the presence of large spindle-shaped and stellate-shaped mononuclear cells and multinucleated cells. These cells occur in a variety of lesions, such as the fibrous papule of the nose, ungual fibroma, acral fibrokeratoma, acral angiofibroma and desmoplastic fibroblastoma (Swan, 1988; Pitt et al., 1993; Karabela-Bouropoulou et al., 1999; Jang et al., 1999). Despite many studies, the nature of the stellated multinucleate and mononuclear cell is not clear (Weathers and Campbell, 1974; Regezi et al., 1987; Odell et al., 1994; Magnusson and Rasmusson, 1995).

Diagnosis

PCNA and Ki67 immunoreactivity happens in case of fibroma and peripheral granuloma.[1]

gollark: Rust, which is COOL™, has monotonic time and system time and such as separate types. Go did *not* have monotonic time for ages, but *did* have an internal function for it which wasn't exposed because of course.
gollark: That article describes, among other things, somewhat poor filesystem interaction handling, and a really stupid way monotonic time was handled.
gollark: https://fasterthanli.me/articles/i-want-off-mr-golangs-wild-ride
gollark: Also, it handles OS interaction poorly and tries to hide complexity sometimes in ways which do not work.
gollark: Go is kind of the opposite, in that it has complicated inconsistent rules to try and look simple.

References
  1. Mighell, Alan J. (1996). "PCNA and Ki-67 immunoreactivity in multinucleated cells of giant cell fibroma and peripheral giant cell granuloma". Journal of Oral Pathology and Medicine. 25 (5): 193–199. doi:10.1111/j.1600-0714.1996.tb01371.x. PMID 8835814.
  • Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.


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