Dinoflagellate luciferase

Dinoflagellate luciferase (EC 1.13.12.18, Gonyaulax luciferase) is a specific luciferase, an enzyme with systematic name dinoflagellate-luciferin:oxygen 132-oxidoreductase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

dinoflagellate luciferin + O2 oxidized dinoflagellate luciferin + H2O + hnu
Dinoflagellate luciferase
Identifiers
EC number1.13.12.18
CAS number303183-71-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Dinoflagellate luciferase is a single protein with three luciferase domains.

References
  1. Dunlap JC, Hastings JW (October 1981). "The biological clock in Gonyaulax controls luciferase activity by regulating turnover". The Journal of Biological Chemistry. 256 (20): 10509–18. PMID 7197271.
  2. Morse D, Pappenheimer AM, Hastings JW (July 1989). "Role of a luciferin-binding protein in the circadian bioluminescent reaction of Gonyaulax polyedra". The Journal of Biological Chemistry. 264 (20): 11822–6. PMID 2745419.
  3. Bae YM, Hastings JW (October 1994). "Cloning, sequencing and expression of dinoflagellate luciferase DNA from a marine alga, Gonyaulax polyedra". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1219 (2): 449–56. doi:10.1016/0167-4781(94)90071-x. PMID 7918642.
  4. Li L (2000). "Gonyaulax luciferase: gene structure, protein expression, and purification from recombinant sources". Methods in Enzymology. 305: 249–58. doi:10.1016/s0076-6879(00)05492-6. ISBN 9780121822064. PMID 10812605.
  5. Morse D, Mittag M (2000). "Dinoflagellate luciferin-binding protein". Methods in Enzymology. 305: 258–76. doi:10.1016/s0076-6879(00)05493-8. ISBN 9780121822064. PMID 10812606.
  6. Schultz LW, Liu L, Cegielski M, Hastings JW (February 2005). "Crystal structure of a pH-regulated luciferase catalyzing the bioluminescent oxidation of an open tetrapyrrole". Proceedings of the National Academy of Sciences of the United States of America. 102 (5): 1378–83. doi:10.1073/pnas.0409335102. PMC 547824. PMID 15665092.


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