Diaminobutyrate decarboxylase
In enzymology, a diaminobutyrate decarboxylase (EC 4.1.1.86) is an enzyme that catalyzes the chemical reaction
- L-2,4-diaminobutanoate propane-1,3-diamine + CO2
| Diaminobutyrate decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.1.86 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Hence, this enzyme has one substrate, L-2,4-diaminobutanoate, and two products, propane-1,3-diamine and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming). Other names in common use include DABA DC, L-2,4-diaminobutyrate decarboxylase, and L-2,4-diaminobutanoate carboxy-lyase.
References
- Yamamoto S, Tsuzaki Y, Tougou K, Shinoda S (1992). "Purification and characterization of L-2,4-diaminobutyrate decarboxylase from Acinetobacter calcoaceticus". J. Gen. Microbiol. 138 (7): 1461–5. doi:10.1099/00221287-138-7-1461. PMID 1512577.
- Ikai H, Yamamoto S (1994). "Cloning and expression in Escherichia coli of the gene encoding a novel L-2,4-diaminobutyrate decarboxylase of Acinetobacter baumannii". FEMS Microbiol. Lett. 124 (2): 225–8. doi:10.1111/j.1574-6968.1994.tb07288.x. PMID 7813892.
- Ikai H, Yamamoto S (1997). "Identification and analysis of a gene encoding L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase involved in the 1,3-diaminopropane production pathway in Acinetobacter baumannii". J. Bacteriol. 179 (16): 5118–25. doi:10.1128/jb.179.16.5118-5125.1997. PMC 179370. PMID 9260954.
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