Dammarenediol II synthase

Dammarenediol II synthase (EC 4.2.1.125, dammarenediol synthase, 2,3-oxidosqualene (20S)-dammarenediol cyclase, DDS, (S)-squalene-2,3-epoxide hydro-lyase (dammarenediol-II forming)) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (dammarenediol-II forming).[1][2] This enzyme catalyses the following chemical reaction

dammarenediol II (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O
Dammarenediol II synthase
Identifiers
EC number4.2.1.125
CAS number189354-84-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The reaction occurs in the reverse direction.

References

  1. Tansakul P, Shibuya M, Kushiro T, Ebizuka Y (October 2006). "Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng". FEBS Letters. 580 (22): 5143–9. doi:10.1016/j.febslet.2006.08.044. PMID 16962103.
  2. Han JY, Kwon YS, Yang DC, Jung YR, Choi YE (December 2006). "Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng". Plant & Cell Physiology. 47 (12): 1653–62. doi:10.1093/pcp/pcl032. PMID 17088293.


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