Corticosteroid side-chain-isomerase
In enzymology, a corticosteroid side-chain-isomerase (EC 5.3.1.21) is an enzyme that catalyzes the chemical reaction
- 11-deoxycorticosterone 20-hydroxy-3-oxopregn-4-en-21-al
| corticosteroid side-chain-isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.3.1.21 | ||||||||
| CAS number | 75139-73-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, 11-deoxycorticosterone, and one product, 20-hydroxy-3-oxopregn-4-en-21-al.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is 11-deoxycorticosterone aldose-ketose-isomerase.
References
- Martin KO, Oh SW, Lee HJ, Monder C (1977). "Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme". Biochemistry. 16 (17): 3803–9. doi:10.1021/bi00636a013. PMID 901753.
- Monder C, Martin KO, Bogumil J (1980). "Presence of epimerase activity in hamster liver corticosteroid side chain isomerase". J. Biol. Chem. 255 (15): 7192–8. PMID 7391077.
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