Cis-abienol synthase

Cis-abienol synthase (EC 4.2.3.140, Z-abienol synthase, CAS, ABS) is an enzyme with systematic name (13E)-8alpha-hydroxylabd-13-en-15-yl-diphosphate-lyase (cis-abienol forming).[1][2] This enzyme catalyses the following chemical reaction

(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate cis-abienol + diphosphate
Cis-abienol synthase
Identifiers
EC number4.2.3.140
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is isolated from the plants Abies balsamea (balsam fir) and Nicotiana tabacum (tobacco).

References

  1. Zerbe P, Chiang A, Yuen M, Hamberger B, Hamberger B, Draper JA, Britton R, Bohlmann J (April 2012). "Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production". The Journal of Biological Chemistry. 287 (15): 12121–31. doi:10.1074/jbc.m111.317669. PMC 3320957. PMID 22337889.
  2. Sallaud C, Giacalone C, Töpfer R, Goepfert S, Bakaher N, Rösti S, Tissier A (October 2012). "Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes". The Plant Journal. 72 (1): 1–17. doi:10.1111/j.1365-313x.2012.05068.x. PMID 22672125.
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