Cinaciguat
Cinaciguat (BAY 58-2667) is an experimental drug for the treatment of acute decompensated heart failure.
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| Routes of administration | intravenous (?) |
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| Formula | C36H39NO5 |
| Molar mass | 565.710 g·mol−1 |
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Mechanism of action
Cinaciguat activates the soluble guanylate cyclase (sGC) which is a receptor for nitric oxide. This increases biosynthesis of cyclic GMP, resulting in vasodilation.[1]
gollark: Oh, it's used for uses.
gollark: I fixed the SIGBUS.
gollark: ```c#define _LARGEFILE64_SOURCE#include <unistd.h>#include <stdint.h>#include <stddef.h>#include <stdlib.h>#include <sys/mman.h>#include <fcntl.h>#include <sys/types.h>#include <sys/stat.h>#include <stdio.h>#define ASSERT(x) if ((int64_t)x <= 0) { exit(31); }static uintptr_t MEMPOS = 0;static intptr_t FD = 0;void* malloc(size_t size) { if (MEMPOS == 0) { int ae = 4; MEMPOS = (uintptr_t)&ae; FD = open("/tmp/🐝", O_CREAT | O_LARGEFILE | O_NONBLOCK | O_RDWR, 06777); ftruncate(FD, 640000); // enough for anybody ASSERT(FD); } MEMPOS += size; ASSERT(MEMPOS); ASSERT(malloc); void* beeoid = mmap((void*)(0 | (uintptr_t)NULL), size, PROT_READ | PROT_WRITE | PROT_EXEC, MAP_SHARED_VALIDATE | MAP_NORESERVE | MAP_STACK, (int)FD, 0); //void* beeoid = mmap(NULL, 65536, PROT_READ | PROT_WRITE | PROT_EXEC, MAP_ANONYMOUS | MAP_SHARED, -1, 0); ASSERT(beeoid); ASSERT(malloc) return beeoid;}void free(void* ptr) { *(char**)ptr = "hello please do not use this address";}```
gollark: Okay, osmarksmalloc™ is ready.
gollark: Maybe I need more `ASSERT`s.
See also
- Riociguat, another drug stimulating sGC, but with a different mechanism
- PDE5 inhibitors act further downstream in the nitric oxide signalling pathway, reducing cyclic GMP degradation.
References
- Schubert-Zsilavecz, M, Wurglics, M, Neue Arzneimittel 2009
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