Chondroitin ABC lyase

Chondroitin ABC lyase (EC 4.2.2.20 EC 4.2.2.21, chondroitinase, chondroitin ABC eliminase, chondroitinase ABC) is an enzyme with systematic name chondroitin ABC lyase.[1][2] This enzyme catalyses the following chemical reaction

Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups
chondroitin-sulfate-ABC endolyase
Identifiers
EC number4.2.2.20
CAS number9024-13-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
chondroitin-sulfate-ABC exolyase
Identifiers
EC number4.2.2.21
CAS number9024-13-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate.

Uses

Following a spinal cord injury, this enzyme can be used to erode scar tissue that can interfere with regeneration.[3]

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gollark: Wait, does esobot store pingwhens in memory or are they persistent?
gollark: ```cIn file included from ../src/statement.cc:6:../src/macros.h:112:22: warning: ‘v8::Local<v8::Value> Nan::MakeCallback(v8::Local<v8::Object>, v8::Local<v8::Function>, int, v8::Local<v8::Value>*)’ is deprecated [-Wdeprecated-declarations] 112 | Nan::MakeCallback((context), (callback), (argc), (argv)) | ~~~~~~~~~~~~~~~~~^~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~../src/macros.h:105:5: note: in expansion of macro ‘TRY_CATCH_CALL’ 105 | TRY_CATCH_CALL((obj), \ | ^~~~~~~~~~~~~~../src/statement.cc:78:9: note: in expansion of macro ‘EMIT_EVENT’ 78 | EMIT_EVENT(stmt->handle(), 2, argv); | ^~~~~~~~~~In file included from ../src/database.h:10, from ../src/statement.cc:7:../../../../nan/nan.h:1026:46: note: declared here 1026 | NAN_DEPRECATED inline v8::Local<v8::Value> MakeCallback(```

References

  1. Yamagata T, Saito H, Habuchi O, Suzuki S (April 1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases". The Journal of Biological Chemistry. 243 (7): 1523–35. PMID 5647268.
  2. Saito H, Yamagata T, Suzuki S (April 1968). "Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates". The Journal of Biological Chemistry. 243 (7): 1536–42. PMID 4231029.
  3. Bartus K, James ND, Didangelos A, Bosch KD, Verhaagen J, Yáñez-Muñoz RJ, Rogers JH, Schneider BL, Muir EM, Bradbury EJ (April 2014). "Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury". The Journal of Neuroscience. 34 (14): 4822–36. doi:10.1523/JNEUROSCI.4369-13.2014. PMC 3972714. PMID 24695702. Lay summary Eureka Alert.
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