Casbene synthase

In enzymology, a casbene synthase (EC 4.2.3.8) is an enzyme that catalyzes the chemical reaction

geranylgeranyl diphosphate casbene + diphosphate
casbene synthase
Identifiers
EC number4.2.3.8
CAS number69106-45-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, geranylgeranyl diphosphate, and two products, casbene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming). Other names in common use include casbene synthetase, and geranylgeranyl-diphosphate diphosphate-lyase (cyclizing). This enzyme participates in diterpenoid biosynthesis.

References

    • Moesta P, West CA (1985). "Casbene synthetase: regulation of phytoalexin biosynthesis in Ricinus communis L. seedlings. Purification of casbene synthetase and regulation of its biosynthesis during elicitation". Arch. Biochem. Biophys. 238 (1): 325–33. doi:10.1016/0003-9861(85)90171-7. PMID 3985625.


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