Calcipressin

In molecular biology, the calcipressin family of proteins negatively regulate calcineurin by direct binding. They are essential for the survival of T helper type 1 cells. Calcipressin 1 is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the conserved FLISPP motif, this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation.[1]

Calcipressin
solution structure of rrm domain in calcipressin 1
Identifiers
SymbolCalcipressin
PfamPF04847
Pfam clanCL0221
InterProIPR006931

In humans, the Calcipressins family of proteins is derived from three genes. Calcipressin 1 is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1). Calcipressin 2 is variously known as MCIP2, ZAKI-4 and DSCR1-like 1. Calcipressin 3 is also called MCIP3 and DSCR1-like 2.[2]

References
  1. Genesca L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, Perez-Riba M (September 2003). "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life". Biochem. J. 374 (Pt 2): 567–75. doi:10.1042/BJ20030267. PMC 1223619. PMID 12809556.
  2. Parry RV, June CH (September 2003). "Calcium-independent calcineurin regulation". Nat. Immunol. 4 (9): 821–3. doi:10.1038/ni0903-821. PMID 12942079.
This article incorporates text from the public domain Pfam and InterPro: IPR006931
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