RCAN3

RCAN3
Identifiers
Aliases	RCAN3, DSCR1L2, MCIP3, RCN3, hRCN3, RCAN family member 3
External IDs	OMIM: 605860 MGI: 1858220 HomoloGene: 8388 GeneCards: RCAN3
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	24,541,040 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	135,433,853 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • troponin I binding; • calcium-dependent protein serine/threonine phosphatase regulator activity; • RNA binding; • nucleic acid binding; • phosphatase binding;
Cellular component	• cytoplasm;
Biological process	• regulation of calcineurin-NFAT signaling cascade; • anatomical structure morphogenesis; • calcium-mediated signaling; • regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	11123
	53902
	ENSG00000117602
	ENSMUSG00000059713
	Q9UKA8
	Q9JKK0
NM_013441; NM_001251977; NM_001251978; NM_001251979; NM_001251980;
	NM_001251981; NM_001251982; NM_001251983; NM_001251984; NM_001251985
	NM_022980
NP_001238906; NP_001238907; NP_001238908; NP_001238909; NP_001238910;
	NP_001238911; NP_001238912; NP_001238913; NP_001238914; NP_038469
	NP_075356
	Wikidata
View/Edit Human	View/Edit Mouse

RCAN3 is a gene that in humans encodes the Calcipressin-3 protein.

Calcipressin-1, which shares a similar function to Calcipressin-3. Both repress calcineurin.

Calcipressin-3 is a protein that in humans is encoded by the RCAN3 gene and is a member of the Calcipressin family of proteins.[5][6]

Expression

RCAN3 is highly expressed in the Cerebellar Hemisphere, Prostrate, and the Mucosa of the esophagus.[7]

Orthologs

RCAN3 was present in the common ancestor of all animals. As a result, orthologs are present in other species, including mice (Rcan3), chickens (RCAN3), and zebrafish (rcan3).[8]

Clinical Significance

Calcipressin-3, along with the other two Calcipressin proteins have been identified as possible contributing factors to Down Syndrome in humans.[9]

Summary box

N/A

gollark: I think msgpack is technically superior, but potatOS doesn't actually ship code for it right now.

gollark: It supports a msgpack-based encoding instead, but none of the clients except the JS-based test one actually use that.

gollark: You can actually use the older v1 protocol (there are no v2 and v3, it's complicated) really easily with wscat or something. There's just no interesting traffic mostly.

gollark: In PotatOS? Nope, the client code is all there, the server doesn't dynamically send extra ones.

gollark: The code for it is in potatOS somewhere.

References

GRCh38: Ensembl release 89: ENSG00000117602 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000059713 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M (May 2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)". Genomics. 64 (3): 252–63. doi:10.1006/geno.2000.6127. PMID 10756093.
"Entrez Gene: DSCR1L2 Down syndrome critical region gene 1-like 2".
"Gene Expression in 53 tissues from GTEx RNA-seq of 8555 samples (570 donors) (RCAN3)". genome.ucsc.edu. Retrieved 2020-06-11.
"RCAN3 Gene - GeneCards | RCAN3 Protein | RCAN3 Antibody". www.genecards.org. Retrieved 2020-06-11.
"InterPro". www.ebi.ac.uk. Retrieved 2020-06-11.

Facchin F, Canaider S, Vitale L, et al. (2008). "Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms". Gene. 407 (1–2): 159–68. doi:10.1016/j.gene.2007.10.006. PMID 18022329.
Mulero MC, Aubareda A, Schlüter A, Pérez-Riba M (2007). "RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression". Biochim. Biophys. Acta. 1773 (3): 330–41. doi:10.1016/j.bbamcr.2006.12.007. PMID 17270291.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Canaider S, Facchin F, Griffoni C, et al. (2006). "Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)". Gene. 372: 128–36. doi:10.1016/j.gene.2005.12.029. PMID 16516408.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117602 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059713 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10756093-5] Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M (May 2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)". Genomics. 64 (3): 252–63. doi:10.1006/geno.2000.6127. PMID 10756093.

[entrez-6] "Entrez Gene: DSCR1L2 Down syndrome critical region gene 1-like 2".

[7] "Gene Expression in 53 tissues from GTEx RNA-seq of 8555 samples (570 donors) (RCAN3)". genome.ucsc.edu. Retrieved 2020-06-11.

[8] "RCAN3 Gene - GeneCards | RCAN3 Protein | RCAN3 Antibody". www.genecards.org. Retrieved 2020-06-11.

[9] "InterPro". www.ebi.ac.uk. Retrieved 2020-06-11.