RCAN3
RCAN3 is a gene that in humans encodes the Calcipressin-3 protein.
Calcipressin-1, which shares a similar function to Calcipressin-3. Both repress calcineurin.
Calcipressin-3 is a protein that in humans is encoded by the RCAN3 gene and is a member of the Calcipressin family of proteins.[5][6]
Expression
RCAN3 is highly expressed in the Cerebellar Hemisphere, Prostrate, and the Mucosa of the esophagus.[7]
Orthologs
RCAN3 was present in the common ancestor of all animals. As a result, orthologs are present in other species, including mice (Rcan3), chickens (RCAN3), and zebrafish (rcan3).[8]
Clinical Significance
Calcipressin-3, along with the other two Calcipressin proteins have been identified as possible contributing factors to Down Syndrome in humans.[9]
Summary box
N/A
gollark: Maybe ABR should gain this ”feature”!
gollark: ?tag bismuth1
gollark: ?tag blub
gollark: ?tag create blub Graham considers a hypothetical Blub programmer. When the programmer looks down the "power continuum", he considers the lower languages to be less powerful because they miss some feature that a Blub programmer is used to. But when he looks up, he fails to realise that he is looking up: he merely sees "weird languages" with unnecessary features and assumes they are equivalent in power, but with "other hairy stuff thrown in as well". When Graham considers the point of view of a programmer using a language higher than Blub, he describes that programmer as looking down on Blub and noting its "missing" features from the point of view of the higher language.
gollark: ?tag blub Graham considers a hypothetical Blub programmer. When the programmer looks down the "power continuum", he considers the lower languages to be less powerful because they miss some feature that a Blub programmer is used to. But when he looks up, he fails to realise that he is looking up: he merely sees "weird languages" with unnecessary features and assumes they are equivalent in power, but with "other hairy stuff thrown in as well". When Graham considers the point of view of a programmer using a language higher than Blub, he describes that programmer as looking down on Blub and noting its "missing" features from the point of view of the higher language.
References
- GRCh38: Ensembl release 89: ENSG00000117602 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000059713 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M (May 2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)". Genomics. 64 (3): 252–63. doi:10.1006/geno.2000.6127. PMID 10756093.
- "Entrez Gene: DSCR1L2 Down syndrome critical region gene 1-like 2".
- "Gene Expression in 53 tissues from GTEx RNA-seq of 8555 samples (570 donors) (RCAN3)". genome.ucsc.edu. Retrieved 2020-06-11.
- "RCAN3 Gene - GeneCards | RCAN3 Protein | RCAN3 Antibody". www.genecards.org. Retrieved 2020-06-11.
- "InterPro". www.ebi.ac.uk. Retrieved 2020-06-11.
Further reading
- Facchin F, Canaider S, Vitale L, et al. (2008). "Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms". Gene. 407 (1–2): 159–68. doi:10.1016/j.gene.2007.10.006. PMID 18022329.
- Mulero MC, Aubareda A, Schlüter A, Pérez-Riba M (2007). "RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression". Biochim. Biophys. Acta. 1773 (3): 330–41. doi:10.1016/j.bbamcr.2006.12.007. PMID 17270291.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Canaider S, Facchin F, Griffoni C, et al. (2006). "Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)". Gene. 372: 128–36. doi:10.1016/j.gene.2005.12.029. PMID 16516408.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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