RCAN2

RCAN2 is a gene that in humans encodes for the protein Calcipressin-2.

RCAN2
Identifiers
Aliases	RCAN2, CSP2, DSCR1L1, MCIP2, RCN2, ZAKI-4, ZAKI4, regulator of calcineurin 2
External IDs	OMIM: 604876 MGI: 1858219 HomoloGene: 130985 GeneCards: RCAN2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.3 Start 46,220,736 bp[1] End 46,491,972 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B3|17 19.77 cM Start 43,801,351 bp[2] End 44,039,516 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium-dependent protein serine/threonine phosphatase regulator activity • nucleic acid binding Cellular component • cytoplasm • cellular component Biological process • regulation of calcineurin-NFAT signaling cascade • calcium-mediated signaling • regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10231	53901
Ensembl	ENSG00000172348	ENSMUSG00000039601
UniProt	Q14206	Q9JHG2
RefSeq (mRNA)	NM_001251973 NM_001251974 NM_005822	NM_001286653 NM_001286654 NM_030598 NM_207649 NM_001357742
RefSeq (protein)	NP_001238902 NP_001238903 NP_005813	NP_001273582 NP_001273583 NP_085101 NP_997532 NP_001344671
Location (UCSC)	Chr 6: 46.22 – 46.49 Mb	Chr 17: 43.8 – 44.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Calcipressin-2 is a protein that in humans is encoded by the RCAN2 gene.[5][6]

Summary box

N/A

See also

• RCAN1
• RCAN3

References

1. GRCh38: Ensembl release 89: ENSG00000172348 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039601 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyazaki T, Kanou Y, Murata Y, Ohmori S, Niwa T, Maeda K, Yamamura H, Seo H (Aug 1996). "Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts". J Biol Chem. 271 (24): 14567–71. doi:10.1074/jbc.271.24.14567. PMID 8662924.
6. "Entrez Gene: DSCR1L1 Down syndrome critical region gene 1-like 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Rothermel B, Vega RB, Yang J, et al. (2000). "A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling". J. Biol. Chem. 275 (12): 8719–25. doi:10.1074/jbc.275.12.8719. PMID 10722714.
• Strippoli P, Lenzi L, Petrini M, et al. (2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)". Genomics. 64 (3): 252–63. doi:10.1006/geno.2000.6127. PMID 10756093.
• Fuentes JJ, Genescà L, Kingsbury TJ, et al. (2000). "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways". Hum. Mol. Genet. 9 (11): 1681–90. doi:10.1093/hmg/9.11.1681. PMID 10861295.
• Cao X, Kambe F, Miyazaki T, et al. (2002). "Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors". Biochem. J. 367 (Pt 2): 459–66. doi:10.1042/BJ20011797. PMC 1222895. PMID 12102656.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Qin L, Zhao D, Liu X, et al. (2007). "Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway". Mol. Cancer Res. 4 (11): 811–20. doi:10.1158/1541-7786.MCR-06-0126. PMID 17114339.
• Gollogly LK, Ryeom SW, Yoon SS (2007). "Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis". J. Surg. Res. 142 (1): 129–36. doi:10.1016/j.jss.2006.10.011. PMC 1995402. PMID 17610901.

External links

• RCAN2 human gene location in the UCSC Genome Browser.
• RCAN2 human gene details in the UCSC Genome Browser.