Caffeoyl-CoA O-methyltransferase

In enzymology, a caffeoyl-CoA O-methyltransferase (EC 2.1.1.104) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + caffeoyl-CoA S-adenosyl-L-homocysteine + feruloyl-CoA
caffeoyl-CoA O-methyltransferase
Identifiers
EC number2.1.1.104
CAS number120433-42-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl methionine and caffeoyl-CoA, whereas its two products are S-adenosylhomocysteine and feruloyl-CoA. A large number of natural products are generated via a step involving this enzyme.[1]

This enzyme is classified to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase. Other names in common use include caffeoyl coenzyme A methyltransferase, caffeoyl-CoA 3-O-methyltransferase, and trans-caffeoyl-CoA 3-O-methyltransferase. This enzyme participates in phenylpropanoid biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1SUI and 1SUS.

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gollark: It's not like they'd keep the API keys in, you'd need one of those anyway.
gollark: What?
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gollark: I mean it wouldn't be that bad.

References
  1. Wout Boerjan, John Ralph, Marie Baucher "Lignin Biosynthesis" Annu. Rev. Plant Biol. 2003, vol. 54, pp. 519–46. doi:10.1146/annurev.arplant.54.031902.134938


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