Bisdisulizole disodium

Bisdisulizole disodium (INN[1]/USAN,[2] trade name Neo Heliopan AP, INCI disodium phenyl dibenzimidazole tetrasulfonate) is a water-soluble organic compound which is added to sunscreens to absorb UVA rays. It is marketed by Symrise.

Bisdisulizole disodium

Names
IUPAC name disodium 2,2'-(1,4-phenylene)bis(6-sulfo-1H-benzimidazole-4-sulfonate)
Identifiers
CAS Number	180898-37-7^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL2111085^N
ChemSpider	9333274^Y
ECHA InfoCard	100.121.951
PubChem CID	11158166
UNII	Z99XUY03BK^Y
InChI InChI=1S/C20H14N4O12S4.2Na/c25-37(26,27)11-5-13-17(15(7-11)39(31,32)33)23-19(21-13)9-1-2-10(4-3-9)20-22-14-6-12(38(28,29)30)8-16(18(14)24-20)40(34,35)36;;/h1-8H,(H,21,23)(H,22,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;/q;2*+1/p-2^Y Key: GLCJMPWWQKKJQZ-UHFFFAOYSA-L^Y InChI=1/C20H14N4O12S4.2Na/c25-37(26,27)11-5-13-17(15(7-11)39(31,32)33)23-19(21-13)9-1-2-10(4-3-9)20-22-14-6-12(38(28,29)30)8-16(18(14)24-20)40(34,35)36;;/h1-8H,(H,21,23)(H,22,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;/q;2*+1/p-2 Key: GLCJMPWWQKKJQZ-NUQVWONBAQ
SMILES C1=CC(=CC=C1C2=NC3=C(C=C(C=C3N2)S(=O)(=O)O)S(=O)(=O)[O-])C4=NC5=C(C=C(C=C5N4)S(=O)(=O)O)S(=O)(=O)[O-].[Na+].[Na+]
Properties
Chemical formula	C20H12N4Na2O12S4
Molar mass	674.55 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

Bisdisulizole disodium is not approved in the United States by the FDA, but it has been approved in the European Union since the year 2000[3] and other parts of the world.[4][5]

References

1. http://ec.europa.eu/enterprise/cosmetics/cosing/index.cfm?fuseaction=search.detailsPDF&id=75792%5B%5D
2. "Statement on a nonproprietary name adopted by the USAN Council: Bisdisulizole disodium" (PDF). American Medical Association. April 4, 2006. Retrieved 2008-01-08.
3. Osstervalder U, Luther H, Herzog B (2001). "Über den Lichtschutzfaktor hinaus - neue effiziente und photostabile UVA-Filter". Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (in German). 44 (5): 463–70. doi:10.1007/s001030170019.
4. "10. Sunscreens" (PDF). Australian regulatory guidelines for OTC medicines. Commonwealth Department of Health and Ageing, Therapeutic Goods Administration. July 1, 2003. p. 14. Archived from the original (PDF) on August 31, 2007. Retrieved 2008-01-08.
5. "Symrise UV protection products" (PDF). Symrise. Archived from the original (PDF) on 2008-08-21. Retrieved 2008-08-10.