Biotin-independent malonate decarboxylase

Biotin-independent malonate decarboxylase (EC 4.1.1.88, malonate decarboxylase (without biotin), malonate decarboxylase, MDC) is an enzyme with systematic name malonate carboxy-lyase (biotin-independent).[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction

malonate + H+ acetate + CO2
Biotin-independent malonate decarboxylase
Identifiers
EC number4.1.1.88
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes.

References
  1. Schmid M, Berg M, Hilbi H, Dimroth P (April 1996). "Malonate decarboxylase of Klebsiella pneumoniae catalyses the turnover of acetyl and malonyl thioester residues on a coenzyme-A-like prosthetic group". European Journal of Biochemistry. 237 (1): 221–8. doi:10.1111/j.1432-1033.1996.0221n.x. PMID 8620876.
  2. Byun, H.S.; Kim, Y.S. (1997). "Subunit organization of bacterial malonate decarboxylases: the smallest δ subunit as an acyl-carrier protein". J. Biochem. Mol. Biol. 30: 132–137.
  3. Hoenke S, Schmid M, Dimroth P (June 1997). "Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli". European Journal of Biochemistry. 246 (2): 530–8. doi:10.1111/j.1432-1033.1997.00530.x. PMID 9208947.
  4. Chohnan S, Fujio T, Takaki T, Yonekura M, Nishihara H, Takamura Y (December 1998). "Malonate decarboxylase of Pseudomonas putida is composed of five subunits". FEMS Microbiology Letters. 169 (1): 37–43. doi:10.1111/j.1574-6968.1998.tb13296.x. PMID 9851033.
  5. Hoenke S, Schmid M, Dimroth P (October 2000). "Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases". Biochemistry. 39 (43): 13233–40. doi:10.1021/bi001154u. PMID 11052676.
  6. Handa S, Koo JH, Kim YS, Floss HG (October 1999). "Stereochemical course of biotin-independent malonate decarboxylase catalysis". Archives of Biochemistry and Biophysics. 370 (1): 93–6. doi:10.1006/abbi.1999.1369. PMID 10496981.
  7. Koo JH, Kim YS (December 1999). "Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus". European Journal of Biochemistry. 266 (2): 683–90. doi:10.1046/j.1432-1327.1999.00924.x. PMID 10561613.
  8. Kim YS (September 2002). "Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application". Journal of Biochemistry and Molecular Biology. 35 (5): 443–51. doi:10.5483/bmbrep.2002.35.5.443. PMID 12359084.
  9. Dimroth P, Hilbi H (July 1997). "Enzymic and genetic basis for bacterial growth on malonate". Molecular Microbiology. 25 (1): 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.
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