Bicyclogermacrene synthase

Bicyclogermacrene synthase (EC 4.2.3.100, Ov-TPS4) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (bicyclogermacrene-forming).[1] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate bicyclogermacrene + diphosphate
Bicyclogermacrene synthase
Identifiers
EC number4.2.3.100
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme from oregano (Origanum vulgare) gives mainly bicyclogermacrene with Mn2+ as a cofactor.

References

  1. Crocoll C, Asbach J, Novak J, Gershenzon J, Degenhardt J (August 2010). "Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis". Plant Molecular Biology. 73 (6): 587–603. doi:10.1007/s11103-010-9636-1. PMID 20419468.
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