Benzoylformate decarboxylase

In enzymology, a benzoylformate decarboxylase (EC 4.1.1.7) is an enzyme that catalyzes the following chemical reaction:

benzoylformate + H+ benzaldehyde + CO2
benzoylformate decarboxylase
Benzoylformate decarboxlyase tetramer, Pseudomonas putida
Identifiers
EC number4.1.1.7
CAS number9025-00-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, benzoylformate, and two products, benzaldehyde and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is benzoylformate carboxy-lyase (benzaldehyde-forming). Other names in common use include phenylglyoxylate decarboxylase, and benzoylformate carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation and toluene and xylene degradation. It employs one cofactor, thiamin diphosphate.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1BFD, 1MCZ, 1PI3, 1PO7, 1Q6Z, 1YNO, 2FN3, and 2FWN.

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References
    • GUNSALUS CF, STANIER RY, GUNSALUS IC (1953). "The enzymatic conversion of mandelic acid to benzoic acid. III Fractionation and properties of the soluble enzymes". J. Bacteriol. 66 (5): 548–53. PMC 317432. PMID 13108854.


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