BRCC3

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.[5][6][7]

BRCC3
Identifiers
Aliases	BRCC3, BRCC36, C6.1A, CXorf53, BRCA1/BRCA2-containing complex subunit 3
External IDs	OMIM: 300617 MGI: 2389572 HomoloGene: 11530 GeneCards: BRCC3
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 155,071,420 bp[1] End 155,123,074 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 75,416,628 bp[2] End 75,454,001 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0010576 enzyme regulator activity • metal ion binding • polyubiquitin modification-dependent protein binding • peptidase activity • GO:0001948 protein binding • hydrolase activity • metallopeptidase activity • thiol-dependent ubiquitin-specific protease activity • Lys63-specific deubiquitinase activity • thiol-dependent ubiquitinyl hydrolase activity Cellular component • cytoplasm • spindle pole • nuclear ubiquitin ligase complex • ubiquitin ligase complex • nucleoplasm • cytoskeleton • cell nucleus • cytosol • BRCA1-A complex • BRISC complex Biological process • response to ionizing radiation • positive regulation of DNA repair • proteolysis • cellular response to DNA damage stimulus • cell division • cell cycle • histone H2A K63-linked deubiquitination • double-strand break repair via nonhomologous end joining • response to X-ray • GO:0048552 regulation of catalytic activity • double-strand break repair • DNA repair • protein deubiquitination • protein K63-linked deubiquitination • signal transduction involved in G2 DNA damage checkpoint • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79184	210766
Ensembl	ENSG00000185515	ENSMUSG00000031201
UniProt	P46736	P46737
RefSeq (mRNA)	NM_001018055 NM_001242640 NM_024332	NM_001166457 NM_001166459 NM_145956 NM_001358736 NM_001358737
RefSeq (protein)	NP_001018065 NP_001229569 NP_077308	NP_001159929 NP_001159931 NP_666068 NP_001345665 NP_001345666
Location (UCSC)	Chr X: 155.07 – 155.12 Mb	Chr X: 75.42 – 75.45 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.[7]

Interactions

BRCC3 has been shown to interact with BRE,[6][8] BRCA2,[6] RAD51,[6] BRCA1,[6] P53[6] and BARD1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000185515 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031201 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenwrick S, Levinson B, Taylor S, Shapiro A, Gitschier J (Jun 1992). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Human Molecular Genetics. 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175.
6. Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R (Nov 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell. 12 (5): 1087–99. doi:10.1016/S1097-2765(03)00424-6. PMID 14636569.
7. "Entrez Gene: BRCC3 BRCA1/BRCA2-containing complex, subunit 3".
8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Human BRCC3 genome location and BRCC3 gene details page in the UCSC Genome Browser.

Further reading

• Fisch P, Forster A, Sherrington PD, Dyer MJ, Rabbitts TH (Dec 1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another". Oncogene. 8 (12): 3271–6. PMID 8247530.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. Check date values in: |year= / |date= mismatch (help)
• Ambroggio XI, Rees DC, Deshaies RJ (Jan 2004). "JAMM: a metalloprotease-like zinc site in the proteasome and signalosome". PLoS Biology. 2 (1): E2. doi:10.1371/journal.pbio.0020002. PMC 300881. PMID 14737182. Check date values in: |year= / |date= mismatch (help)
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Boudreau HE, Broustas CG, Gokhale PC, Kumar D, Mewani RR, Rone JD, Haddad BR, Kasid U (Jan 2007). "Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation". International Journal of Molecular Medicine. 19 (1): 29–39. doi:10.3892/ijmm.19.1.29. PMID 17143545.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.