BNR/Asp-box repeat

BNR/Asp-box repeat is a repetitive sequence of amino acids contained in some proteins.

BNR/Asp-box repeat
Structure of a bacterial sialidase.[1]
Identifiers
SymbolBNR
PfamPF02012
Pfam clanCL0434
InterProIPR002860
SCOPe1euu / SUPFAM

Members of this family contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes. The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. These repeats are found in a variety of non-homologous proteins, including bacterial ribonucleases, sulphite oxidases, reelin, netrins, sialidases, neuraminidases, some lipoprotein receptors, and a variety of glycosyl hydrolases.[2]

Members of this family contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes.


Examples

Human genes encoding proteins containing this domain include:

gollark: Really? Storage is very cheap now.
gollark: [REDACTED]
gollark: It is not* a cognitohazard.
gollark: Maybe THIS will change your mind.
gollark: It used to be chemical rockets, but those were costlier to send up in bulk.

References
  1. Gaskell A, Crennell S, Taylor G (November 1995). "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll". Structure. 3 (11): 1197–205. doi:10.1016/s0969-2126(01)00255-6. PMID 8591030.
  2. Copley RR, Russell RB, Ponting CP (February 2001). "Sialidase-like Asp-boxes: sequence-similar structures within different protein folds". Protein Science. 10 (2): 285–92. doi:10.1110/ps.31901. PMC 2373934. PMID 11266614.
This article incorporates text from the public domain Pfam and InterPro: IPR002860
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