Aphidicolan-16beta-ol synthase

Aphidicolan-16beta-ol synthase (EC 4.2.3.42, PbACS) is an enzyme with systematic name 9alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16beta-ol-forming).[1][2] This enzyme catalyses the following chemical reaction

9alpha-copalyl diphosphate + H2O aphidicolan-16beta-ol + diphosphate
Aphidicolan-16beta-ol synthase
Identifiers
EC number4.2.3.42
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This is a bifunctional enzyme, which also has EC 5.5.1.14 activity.

References

  1. Oikawa H, Toyomasu T, Toshima H, Ohashi S, Kawaide H, Kamiya Y, Ohtsuka M, Shinoda S, Mitsuhashi W, Sassa T (May 2001). "Cloning and functional expression of cDNA encoding aphidicolan-16 beta-ol synthase: a key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin". Journal of the American Chemical Society. 123 (21): 5154–5. doi:10.1021/ja015747j. PMID 11457369.
  2. Toyomasu T, Nakaminami K, Toshima H, Mie T, Watanabe K, Ito H, Matsui H, Mitsuhashi W, Sassa T, Oikawa H (January 2004). "Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha". Bioscience, Biotechnology, and Biochemistry. 68 (1): 146–52. doi:10.1271/bbb.68.146. PMID 14745177.
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