Amino-acid racemase

In enzymology, an amino-acid racemase (EC 5.1.1.10) is an enzyme that catalyzes the chemical reaction

an L-amino acid a D-amino acid
amino-acid racemase
Identifiers
EC number5.1.1.10
CAS number9068-61-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, L-amino acid, and one product, D-amino acid.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is amino-acid racemase. This enzyme is also called L-amino acid racemase. This enzyme participates in 4 metabolic pathways: glycine, serine and threonine metabolism, cysteine metabolism, D-glutamine and D-glutamate metabolism, and D-arginine and D-ornithine metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2FKP, 2GGG, 2GGH, 2GGI, and 2GGJ.

gollark: What if someone is, say, simulating the entire physical universe including my brain?
gollark: I would also still consider me to be me if my brain is somehow shut down for a bit then turned back on, as long as it doesn't lose any (much?) data while off.
gollark: I an going to go to sleep soon. When I wake up after being unconscious for a bit, I still consider it me.
gollark: Sure!
gollark: "We scan your brain structure while it's not running/very fast and emulate it on a computer" is simple enough.

References
    • Soda K, Osumi T (1969). "Crystalline amino acid racemase with low substrate specificity". Biochem. Biophys. Res. Commun. 35 (3): 363–8. doi:10.1016/0006-291X(69)90507-5. PMID 5788493.


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