Alpha-amyrin synthase

Alpha-amyrin synthase (EC 5.4.99.40, 2,3-oxidosqualene alpha-amyrin cyclase, mixed amyrin synthase) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, alpha-amyrin-forming).[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene alpha-amyrin
Alpha-amyrin synthase
Identifiers
EC number5.4.99.40
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This multifunctional enzyme produces both alpha- and beta-amyrin.

References

  1. Morita M, Shibuya M, Kushiro T, Masuda K, Ebizuka Y (June 2000). "Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase". European Journal of Biochemistry. 267 (12): 3453–60. doi:10.1046/j.1432-1327.2000.01357.x. PMID 10848960.
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