Aldos-2-ulose dehydratase

Aldos-2-ulose dehydratase (EC 4.2.1.110, pyranosone dehydratase, AUDH, 1,5-anhydro-D-fructose dehydratase (microthecin-forming)) is an enzyme with systematic name 1,5-anhydro-D-fructose hydro-lyase (microthecin-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

1,5-anhydro-D-fructose 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O (overall reaction)
(1a) 1,5-anhydro-D-fructose 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O
(1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one
Aldos-2-ulose dehydratase
Identifiers
EC number4.2.1.110
CAS number101920-80-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme catalyses two of the steps in the anhydrofructose pathway.

References
  1. Yu S, Fiskesund R (September 2006). "The anhydrofructose pathway and its possible role in stress response and signaling". Biochimica et Biophysica Acta (BBA) - General Subjects. 1760 (9): 1314–22. doi:10.1016/j.bbagen.2006.05.007. PMID 16822618.
  2. Yu S (May 2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochimica et Biophysica Acta. 1723 (1–3): 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID 15716041.
  3. Broberg, A.; Kenne, L.; Pedersén, M. (1996). "Presence of microthecin in the red alga Gracilariopsis lemaneiformis and its formation from 1,5-anhydro-D-fructose". Phytochemistry. 41: 151–154. doi:10.1016/0031-9422(95)00587-0.
  4. Gabriel J, Volc J, Sedmera P, Daniel G, Kubátová E (1993). "Pyranosone dehydratase from the basidiomycete Phanerochaete chrysosporium: improved purification, and identification of 6-deoxy-D-glucosone and D-xylosone reaction products". Archives of Microbiology. 160 (1): 27–34. doi:10.1007/BF00258142 (inactive 2020-05-25). PMID 8352649.
  5. Yu S, Refdahl C, Lundt I (May 2004). "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and alpha-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochimica et Biophysica Acta. 1672 (2): 120–9. doi:10.1016/j.bbagen.2004.03.004. PMID 15110094.
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