AS3MT

Arsenite methyltransferase is an enzyme that in humans is encoded by the AS3MT gene.[5][6]

AS3MT
Identifiers
Aliases	AS3MT, CYT19, arsenite methyltransferase
External IDs	OMIM: 611806 MGI: 1929882 HomoloGene: 10754 GeneCards: AS3MT
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.32 Start 102,869,470 bp[1] End 102,901,899 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 46,707,458 bp[2] End 46,741,099 bp[2]
Gene ontology Molecular function • methyltransferase activity • transferase activity • methylarsonite methyltransferase activity • arsenite methyltransferase activity Cellular component • cytosol • cytoplasm Biological process • toxin metabolic process • arsonoacetate metabolic process • methylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57412	57344
Ensembl	ENSG00000214435	ENSMUSG00000003559
UniProt	Q9HBK9	Q91WU5
RefSeq (mRNA)	NM_020682	NM_020577
RefSeq (protein)	NP_065733	NP_065602
Location (UCSC)	Chr 10: 102.87 – 102.9 Mb	Chr 19: 46.71 – 46.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000214435 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003559 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ (March 2002). "A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol". The Journal of Biological Chemistry. 277 (13): 10795–803. doi:10.1074/jbc.M110246200. PMID 11790780.
6. "Entrez Gene: AS3MT arsenic (+3 oxidation state) methyltransferase".

Further reading

• Dheeman DS, Packianathan C, Pillai JK, Rosen BP (November 2014). "Pathway of human AS3MT arsenic methylation". Chemical Research in Toxicology. 27 (11): 1979–89. doi:10.1021/tx500313k. PMC 4237493. PMID 25325836.
• Hernández A, Xamena N, Sekaran C, Tokunaga H, Sampayo-Reyes A, Quinteros D, Creus A, Marcos R (April 2008). "High arsenic metabolic efficiency in AS3MT287Thr allele carriers". Pharmacogenetics and Genomics. 18 (4): 349–55. doi:10.1097/FPC.0b013e3282f7f46b. PMID 18334919.
• Fujihara J, Kunito T, Agusa T, Yasuda T, Iida R, Fujii Y, Takeshita H (December 2007). "Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method". Toxicology and Applied Pharmacology. 225 (3): 251–4. doi:10.1016/j.taap.2007.08.010. PMID 17889916.
• Hernández A, Xamena N, Surrallés J, Sekaran C, Tokunaga H, Quinteros D, Creus A, Marcos R (January 2008). "Role of the Met(287)Thr polymorphism in the AS3MT gene on the metabolic arsenic profile". Mutation Research. 637 (1–2): 80–92. doi:10.1016/j.mrfmmm.2007.07.004. PMID 17850829.
• Lindberg AL, Kumar R, Goessler W, Thirumaran R, Gurzau E, Koppova K, Rudnai P, Leonardi G, Fletcher T, Vahter M (July 2007). "Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms". Environmental Health Perspectives. 115 (7): 1081–6. doi:10.1289/ehp.10026. PMC 1913583. PMID 17637926.
• Schläwicke Engström K, Broberg K, Concha G, Nermell B, Warholm M, Vahter M (April 2007). "Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina". Environmental Health Perspectives. 115 (4): 599–605. doi:10.1289/ehp.9734. PMC 1852682. PMID 17450230.
• Meza M, Gandolfi AJ, Klimecki WT (August 2007). "Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?". Toxicology and Applied Pharmacology. 222 (3): 381–7. doi:10.1016/j.taap.2006.12.018. PMC 2040165. PMID 17306849.
• Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM (March 2006). "Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies". The Journal of Biological Chemistry. 281 (11): 7364–73. doi:10.1074/jbc.M512227200. PMID 16407288.
• Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT (June 2005). "Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children". Environmental Health Perspectives. 113 (6): 775–81. doi:10.1289/ehp.7780. PMC 1257606. PMID 15929903.
• Li J, Waters SB, Drobna Z, Devesa V, Styblo M, Thomas DJ (April 2005). "Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype" (PDF). Toxicology and Applied Pharmacology. 204 (2): 164–9. doi:10.1016/j.taap.2004.12.002. PMID 15808521.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• Human AS3MT genome location and AS3MT gene details page in the UCSC Genome Browser.