ACO1

Function

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.[4]

gollark: Well, the whole thing of "let's GET RID OF ENCRYPTION we're so smart TERRORISTS" is really a political issue.
gollark: I did say "non-proud UK-dweller", you know.
gollark: Paraphrased: "Who cares what your MATHS says about it not being possible to have encryption only the government can break, we want this impossible thing done by Tuesday!"
gollark: “Well the laws of Australia prevail in Australia, I can assure you of that. The laws of mathematics are very commendable, but the only law that applies in Australia is the law of Australia," - former prime minister.
gollark: Mostly because the politicians are just utterly moronic.

References
  1. GRCh38: Ensembl release 89: ENSG00000122729 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: Aconitase 1, soluble".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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