5-dehydro-4-deoxyglucarate dehydratase

In enzymology, a 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) is an enzyme that catalyzes the chemical reaction

5-dehydro-4-deoxy-D-glucarate 2,5-dioxopentanoate + H2O + CO2
5-dehydro-4-deoxyglucarate dehydratase
Identifiers
EC number4.2.1.41
CAS number37290-77-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, 5-dehydro-4-deoxy-D-glucarate, but three products: 2,5-dioxopentanoate, H2O, and CO2.

Enzyme class

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating 2,5-dioxopentanoate-forming). Other names in common use include 5-keto-4-deoxy-glucarate dehydratase, deoxyketoglucarate dehydratase, D-4-deoxy-5-ketoglucarate hydro-lyase, and 5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating). This enzyme participates in ascorbate and aldarate metabolism.

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References

    • Jeffcoat R, Hassall H, Dagley S (1969). "Purification and properties of D-4-deoxy-5-oxoglucarate hydro-lyase (decarboxylating)". Biochem. J. 115 (5): 977–83. PMC 1185240. PMID 4982840.


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