5-dehydro-4-deoxyglucarate dehydratase
In enzymology, a 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) is an enzyme that catalyzes the chemical reaction
- 5-dehydro-4-deoxy-D-glucarate 2,5-dioxopentanoate + H2O + CO2
| 5-dehydro-4-deoxyglucarate dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.41 | ||||||||
| CAS number | 37290-77-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, 5-dehydro-4-deoxy-D-glucarate, but three products: 2,5-dioxopentanoate, H2O, and CO2.
Enzyme class
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating 2,5-dioxopentanoate-forming). Other names in common use include 5-keto-4-deoxy-glucarate dehydratase, deoxyketoglucarate dehydratase, D-4-deoxy-5-ketoglucarate hydro-lyase, and 5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating). This enzyme participates in ascorbate and aldarate metabolism.
References
- Jeffcoat R, Hassall H, Dagley S (1969). "Purification and properties of D-4-deoxy-5-oxoglucarate hydro-lyase (decarboxylating)". Biochem. J. 115 (5): 977–83. PMC 1185240. PMID 4982840.