4-hydroxybenzoate decarboxylase

In enzymology, a 4-hydroxybenzoate decarboxylase (EC 4.1.1.61) is an enzyme that catalyzes the chemical reaction

4-hydroxybenzoate phenol + CO2
4-hydroxybenzoate decarboxylase
Identifiers
EC number4.1.1.61
CAS number37290-53-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, 4-hydroxybenzoate, and two products, phenol and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxybenzoate carboxy-lyase (phenol-forming). Other names in common use include p-hydroxybenzoate decarboxylase, and 4-hydroxybenzoate carboxy-lyase. This enzyme participates in benzoate degradation via coa ligation.

References

    • Grant DJ, Patel JC (1969). "The non-oxidative decarboxylation of p-hydroxybenzoic acid, gentisic acid, protocatechuic acid and gallic acid by Klebsiella aerogenes (Aerobacter aerogenes)". Antonie van Leeuwenhoek. 35 (3): 325–43. doi:10.1007/BF02219153. PMID 5309907.
    • Tschech A, Fuchs G (1989). "Anaerobic degradation of phenol via carboxylation to 4-hydroxybenzoate - in vitro study of isotope exchange between (CO2)-C-14 and 4-hydroxybenzoate". Arch. Microbiol. 152 (6): 594–599. doi:10.1007/BF00425493.


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